1035262-24-8

Upstream product

• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 
• 3218-49-3 3,4-dichloro-benzeneacetonitrile 
• 111-44-4 3-oxa-1,5-dichloropentane 

Downstream Products

• 1035262-25-9 4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carboxylic acid 
• 1358804-95-1 (4-(3,4-dichlorophenyl)tetrahydro-2H-pyran-4-yl)(pyridin-2-yl)methanone 
• 1358803-77-6 [4-(3,4-dichlorophenyl)tetrahydro-2H-pyran-4-yl](pyridin-2-yl)methanol 
• 1040860-93-2 C₁₂H₁₁Cl₃O₂ 
• 1035262-26-0 diethyl 2-(4-(3,4-dichlorophenyl)-tetrahydro-2H-pyran-4-carbonyl)malonate 

Relevant academic research and scientific papers

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (I) wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specification. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds and compositions are also presented.

NOVEL TRPV3 MODULATORS

Disclosed herein are modulators of TRPV3 of formula (I), wherein G1, X1, X2, X3, X4, X5, G2, Z1, Ra, Rb, u, and p are as defined in the specifica

PYRROLIDINE TRIPLE REUPTAKE INHIBITORS

In various embodiments, the present invention provides cycloalkyl pyrrolidine compounds and methods for their use in the treatment and/or prevention of various diseases, conditions and syndromes, including central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.

NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF

Compounds of Formula (I) and Formula (II) are useful as inhibitors of HIF prolyl hydroxylases. Compounds of Formula(I) and Formula (II) have the following structures, where the definitions of the variables are provided herein.