1035377-16-2Relevant academic research and scientific papers
Successive copper(I)-catalyzed cross-couplings in one pot: A novel and efficient starting point for synthesis of carbapenems
Jiang, Biao,Tian, Hua,Huang, Zuo-Gang,Xu, Min
, p. 2737 - 2740 (2008)
(Chemical Equation Presented) An efficient approach for synthesizing a series of 2-sulfide carbapenems has been developed using two successive Cu(I)-catalyzed crosscouplings in a single pot. The method involves highly selective intramolecular coupling of lactam and dihaloalkene using 2,2′-bipyridine as a ligand, followed by intermolecular C-S formation in the presence of another ligand (1,10-phenanthroline, PPh3) and mercaptan.
