103546-10-7

Basic information

• Product Name: 3-(2-Nitrophenoxy)propylamine
• Synonyms: 3-(2-Nitrophenoxy)propylamine;3-(2-nitrophenoxy)-1-Propanamine;3-(2-NITROPHENOXY)PROPAN-1-AMINE
• CAS NO: 103546-10-7
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196
• Mol File: 103546-10-7.mol

Chemical Properties

• Boiling Point: 353°C at 760 mmHg
• Flash Point: 167.3°C
• Appearance: /
• Density: 1.211g/cm³
• Vapor Pressure: 3.69E-05mmHg at 25°C
• Refractive Index: 1.558
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(2-Nitrophenoxy)propylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Nitrophenoxy)propylamine(103546-10-7)
• EPA Substance Registry System: 3-(2-Nitrophenoxy)propylamine(103546-10-7)

Safety Data

• Hazardous Substances Data: 103546-10-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
3-(2-Nitrophenoxy)propylamine is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the formation of complex molecular structures that can exhibit therapeutic effects.
Used in Organic Chemistry:
In the realm of organic chemistry, 3-(2-Nitrophenoxy)propylamine is used as a versatile intermediate, facilitating the creation of a range of organic compounds due to its reactive functional groups.
Used in Research Laboratories:
3-(2-Nitrophenoxy)propylamine is utilized in research settings to explore its unique chemical properties and potential applications in chemical reactions and compound development.
Used in Drug Production:
As a starting material in the production of various drugs, 3-(2-Nitrophenoxy)propylamine plays a significant role in the pharmaceutical industry, contributing to the development of new medications and therapies.
It is important to handle 3-(2-Nitrophenoxy)propylamine with care due to its potential health hazards if not used properly, emphasizing the need for safety measures in its application across different industries.

InChI:InChI=1/C9H12N2O3/c10-6-3-7-14-9-5-2-1-4-8(9)11(12)13/h1-2,4-5H,3,6-7,10H2

Upstream product

• 66725-23-3 N-<3-(o-Nitrophenoxy)propyl>phthalimide 
• 88-75-5 2-hydroxynitrobenzene 
• 104147-69-5 1-(3-bromopropoxy)-2-nitrobenzene 

Downstream Products

• 103523-46-2 α-isopropyl-3,4,5-trimethoxy-α-<3-<<3-(2-nitrophenoxy)propyl>amino>propyl>benzeneacetonitrile 
• 103523-48-4 α-<3-<<3-(2-aminophenoxy)propyl>amino>propyl>-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile 
• 103523-52-0 α-<3--N-methylamino>propyl>-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile 
• 103523-50-8 α-isopropyl-3,4,5-trimethoxy-α-<3--N-methylamino>propyl>benzeneacetonitrile 

Relevant articles and documents

Selective small molecules blocking HIV-1 tat and coactivator PCAF association

Development of drug resistance from mutations in the targeted viral proteins leads to continuation of viral production by chronically infected cells, contributing to HIV-mediated immune dysfunction. Targeting a host cell protein essential for viral reproduction, rather than a viral protein, may minimize the viral drug resistance problem as observed with HIV protease inhibitors. We report here the development of a novel class of N1-aryl-propane-1,3-diamine compounds using a structure-based approach that selectively inhibit the activity of the bromodomain of the human transcriptional co-activator PCAF, of which association with the HIV trans-activator Tat is essential for transcription and replication of the integrated HIV provirus. Copyright