66725-23-3 Usage
Appearance
Yellow to brown The compound has a yellow to brown color in its solid form.
Usage
Pharmaceutical intermediate and organic synthesis It is commonly used as an intermediate in the synthesis of pharmaceuticals and other organic compounds.
Functional groups
Nitro group and phenoxy group The presence of these groups makes the compound useful for the production of various drugs and other organic compounds.
Precautions
Harmful if swallowed, inhaled, or in contact with skin The compound should be handled with care to avoid potential health risks.
Storage
Cool, dry, and well-ventilated area away from incompatible substances Proper storage conditions help maintain the stability and safety of the compound.
Check Digit Verification of cas no
The CAS Registry Mumber 66725-23-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,6,7,2 and 5 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 66725-23:
(7*6)+(6*6)+(5*7)+(4*2)+(3*5)+(2*2)+(1*3)=143
143 % 10 = 3
So 66725-23-3 is a valid CAS Registry Number.
66725-23-3Relevant academic research and scientific papers
Selective small molecules blocking HIV-1 tat and coactivator PCAF association
Zeng, Lei,Li, Jiaming,Muller, Michaela,Yan, Sherry,Mujtaba, Shiraz,Pan, Chongfeng,Wang, Zhiyong,Zhou, Ming-Ming
, p. 2376 - 2377 (2007/10/03)
Development of drug resistance from mutations in the targeted viral proteins leads to continuation of viral production by chronically infected cells, contributing to HIV-mediated immune dysfunction. Targeting a host cell protein essential for viral reproduction, rather than a viral protein, may minimize the viral drug resistance problem as observed with HIV protease inhibitors. We report here the development of a novel class of N1-aryl-propane-1,3-diamine compounds using a structure-based approach that selectively inhibit the activity of the bromodomain of the human transcriptional co-activator PCAF, of which association with the HIV trans-activator Tat is essential for transcription and replication of the integrated HIV provirus. Copyright
