217650-36-7Relevant academic research and scientific papers
Development of DIOP derivatives as efficient ligands for asymmetric hydrogenation: Factors controlling the reactivities and enantioselectivities
Liu, Duan,Li, Wenge,Zhang, Xumu
, p. 2181 - 2184 (2007/10/03)
Several DIOP derivatives have been developed as efficient ligands for Rh and Ir-catalyzed asymmetric hydrogenations. The conformational mobility of the backbone in this type of ligand plays an important role in governing both the reactivity and enantioselectivity. Isolation of pure pre-catalyst is another key factor to obtain high catalytic activity.
Chiral C2-symmetric ligands with 1,4-dioxane backbone derived from tartrates: Syntheses and applications in asymmetric hydrogenation
Li, Wenge,Waldkirch, Jason P.,Zhang, Xumu
, p. 7618 - 7623 (2007/10/03)
Chiral 1,4-diphenylphosphines 5-7 as well as thioether 8 were synthesized from tartrates employing Ley's "BDA" and "Dispoke" methodologies as the key step. Rhodium(I) complexes with 5-7 are efficient catalysts for the asymmetric hydrogenation of β-substituted enamides and MOM-protected β-hydroxyl enamides, which furnished chiral amines or β-amino alcohols with 94-99% ee. These results indicated that the 1,4-dioxane backbone in the ligands having the general structure 2 played an important role in stabilizing metal-ligand chelate conformation. Higher enantioselectivities with ligand 2 were achieved compared with the analogous ligands having the general structure 1.
