1035486-76-0Relevant academic research and scientific papers
Tungsten-catalyzed regio- and enantioselective aminolysis of trans-2,3-epoxy alcohols: An entry to virtually enantiopure amino alcohols
Wang, Chuan,Yamamoto, Hisashi
, p. 13920 - 13923 (2014)
The first catalytic enantioselective aminolysis of trans-2,3-epoxy alcohols has been accomplished. This stereo-specific ring-opening process was efficiently promoted by a tungsten/bis(hydroxamic acid) catalytic system, furnishing various anti-3-amino-1,2-diols with excellent regiocontrol and high enantioselectivities (up to 95% ee). Moreover, virtually enantiopure 3-amino-1,2-diols could be obtained by the sequential combination of two reactions that both involve the use of a chiral catalyst.
