1035490-73-3

Basic information

• Product Name: (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol
• Synonyms: (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol;(2R)-2-AMINO-2-[3-(TRIFLUOROMETHYL)PHENYL]ETHAN-1-OL;(R)-2-aMino-2-(3-(trifluoroMethyl)phenyl)ethanol HCl;(R)-2-amino-2-(3-(trifluoromethyl)phenyl)ethan-1-ol
• CAS NO: 1035490-73-3
• Molecular Formula: C9H11ClF3NO
• Molecular Weight: 241.6379496
• Mol File: 1035490-73-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol(1035490-73-3)
• EPA Substance Registry System: (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol(1035490-73-3)

Safety Data

• Hazardous Substances Data: 1035490-73-3(Hazardous Substances Data)

Usage

General Description

"(R)-2-Amino-2-(3-trifluoromethylphenyl)ethanol" is a chemical compound with the formula C9H12F3NO. It is an amino alcohol derivative that contains a fluorinated phenyl group. (R)-2-AMino-2-(3-trifluoroMethylphenyl)ethanol is chiral, with its stereochemistry designated as (R). It is commonly used as a reagent in organic synthesis, particularly in the synthesis of pharmaceuticals and agrochemicals. The trifluoromethyl substituent on the phenyl group can impart unique properties to the molecule, making it useful in various chemical reactions. Additionally, the presence of the amino and hydroxyl groups also makes it a versatile building block for the synthesis of other complex compounds.

Upstream product

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• 1312719-03-1 (Rs)-N-(2-(tert-butyldimethylsilyloxy)-1-(3-(trifluoromethyl)phenyl)ethylidene)-2-methylpropane-2-sulfinamide 
• 1312718-92-5 2-(tert-butyldimethylsilyloxy)-1-(3-(trifluoromethyl)phenyl)ethanone 

Relevant articles and documents

Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions

The utilization of N-centered radicals to synthesize nitrogen-containing compounds has attracted considerable attention recently, due to their powerful reactivities and the concomitant construction of C?N bonds. However, the generation and control of N-centered radicals remain particularly challenging. We report a tethering strategy using SOMO-HOMO-converted distonic radical anions for the site-specific aminations of imidates and amidines with aid of the non-covalent interaction. This reaction features a remarkably broad substrate scope and also enables the late-stage functionalization of bioactive molecules. Furthermore, the reaction mechanism is thoroughly investigated through kinetic studies, Raman spectroscopy, electron paramagnetic resonance spectroscopy, and density functional theory calculations, revealing that the aminations likely involve direct homolytic cleavage of N?H bonds and subsequently controllable 1,5 or 1,6 hydrogen atom transfer.

Formal aromatic C-H insertion for stereoselective isoquinolinone synthesis and studies on mechanistic insights into the C-C bond formation

(Chemical Equation Presented) Formal aromatic C-H insertion of rhodium(II) carbenoid was intensively investigated to develop a new methodology and probe its mechanism. Contrasting with the previously proposed direct C-H insertion, the mechanism was revealed to be electrophilic aromatic substitution, which was supported by substituent effects on the aromatic ring and a secondary deuterium kinetic isotope effect. Various isoquinolinones were synthesized intramolecularly via six-membered ring formation with high regioand diastereoselectivity, while averting the common Buchner-type reaction. Intermolecularly, dirhodium catalyzed formal aromatic C-H insertion on electron-rich aromatics was also achieved.