103554-42-3

Usage

Derivative of benzoic acid

It is a modified version of benzoic acid This means that the compound is structurally related to benzoic acid, with some modifications in its chemical structure.

Contains a tert-butyl group

The presence of a tert-butyl group (C4H9) This is a specific type of alkyl group that is part of the compound's structure.

Contains a phenylamino group

The presence of a phenylamino group (C6H5NH2) This is another specific functional group in the compound's structure.

Used in the pharmaceutical industry

As an intermediate in the synthesis of various medications and dyes This indicates that the compound plays a role in the production of other pharmaceuticals and dyes.

Exhibits anti-inflammatory and analgesic properties

It has the potential to reduce inflammation and relieve pain This suggests that the compound may be useful in the development of new therapeutic drugs for pain and inflammation.

Important building block in the production of various pharmaceutical and cosmetic products

It is a key component in the synthesis of other compounds This highlights the compound's significance in the creation of a wide range of products in the pharmaceutical and cosmetic industries.

InChI:InChI=1/C17H19NO2/c1-17(2,3)13-9-5-7-11-15(13)18-14-10-6-4-8-12(14)16(19)20/h4-11,18H,1-3H3,(H,19,20)

Upstream product

• 6310-21-0 2-(1,1-dimethylethyl)-benzenamine 
• 118-91-2 ortho-chlorobenzoic acid 
• 88-65-3 2-bromobenzoic-acid 

Relevant academic research and scientific papers

Regioselective copper-catalyzed amination of chlorobenzoic acids: Synthesis and solid-state structures of N-aryl anthranilic acid derivatives

A chemo- and regioselective copper-catalyzed cross-coupling reaction for effective amination of 2-chlorobenzoic acids with aniline derivatives has been developed. The method eliminates the need for acid protection and produces a wide range of N-aryl anthranilic acid derivatives in up to 99% yield. The amination was found to proceed with both electron-rich and electron-deficient aryl chlorides and anilines and also utilizes sterically hindered anilines such as 2,6-dimethylaniline and 2-tert-butylaniline. The conformational isomerism of appropriately substituted N-aryl anthranilic acids has been investigated in the solid state. Crystallographic analysis of seven anthranilic acid derivatives showed formation of two distinct supramolecular architectures exhibiting trans-anti and unprecedented trans-syn dimeric structures.

Regioselective copper-catalyzed amination of bromobenzoic acids using aliphatic and aromatic amines

A chemo- and regioselective copper-catalyzed cross-coupling procedure for amination of 2-bromobenzoic acids is described. The method eliminates the need for acid protection and produces N-aryl and N-alkyl anthranilic acid derivatives in up to 99% yield. N-(1-Pyrene)anthranilic acid has been employed in metal ion-selective fluorosensing. Titration experiments showed that this pyrene-derived amino acid forms an equimolar complex with Hg(II) in water resulting in selective fluorescence quenching even in the presence of other metal ions such as Zn(II) and Cd(II).