1035556-29-6

Basic information

• Product Name: 3-(4-methoxybenzyl)-6-(methylamino)pyrimidin-4(3H)-one
• Synonyms: 3-(4-methoxybenzyl)-6-(methylamino)pyrimidin-4(3H)-one
• CAS NO: 1035556-29-6
• Molecular Weight: 245.281
• Mol File: 1035556-29-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-(4-methoxybenzyl)-6-(methylamino)pyrimidin-4(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-methoxybenzyl)-6-(methylamino)pyrimidin-4(3H)-one(1035556-29-6)
• EPA Substance Registry System: 3-(4-methoxybenzyl)-6-(methylamino)pyrimidin-4(3H)-one(1035556-29-6)

Safety Data

• Hazardous Substances Data: 1035556-29-6(Hazardous Substances Data)

Upstream product

• 1122-67-4 6-(methylamino)pyrimidin-4(3H)-one 
• 623-12-1 4-chloromethoxybenzene 
• 698-82-8 3-methyl-6-methylamino-3H-pyrimidin-4-one 

Downstream Products

• 1035556-30-9 5-hydroxy-3-(4-methoxybenzyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione 
• 1035555-53-3 (R)-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione 
• 1035555-58-8 (S)-3-(2,3-dihydroxypropyl)-5-(2-fluoro-4-iodophenylamino)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione 
• 1035555-59-9 5-(2-fluoro-4-iodophenylamino)-3-(2-hydroxyethyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione 
• 1035555-57-7 5-(2-fluoro-4-iodophenylamino)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione 
• 1035556-31-0 5-chloro-3-(4-methoxybenzyl)-6,8-dimethylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione 

Relevant articles and documents

Discovery of TAK-733, a potent and selective MEK allosteric site inhibitor for the treatment of cancer

A novel 5-phenylamino-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione series of MEK inhibitors has been developed using structure-based drug design. Lead optimization of this series led to the discovery of TAK-733. This was advanced to Phase I clinical studies for cancer treatment.