103558-98-1

Upstream product

• 103559-05-3 C₁₀H₂₁NOSi 
• 333-27-7 methyl trifluoromethanesulfonate 
• 4229-44-1 N-methylhydroxyamine hydrochloride 
• 2043-61-0 cyclohexanecarbaldehyde 
• 593-77-1 N-Methylhydroxylamine 
• 420-37-1 trimethoxonium tetrafluoroborate 

Downstream Products

• 6830-84-8 N-methylcyclohexanecarboxamide 
• 100812-15-5 N-<1-(1-hydroxycyclohexyl)methyl>-N-methyl-1,1-dimethylpropanamide 
• 100812-16-6 N-(2,2-dimethylpropanoyl)-N-cyclohexanoylmethanamine 
• 100812-03-1 N-<((1-2,2-dimethylpropanoyl)oxy)cyclohexyl)methylidene>methanamide 
• 89332-93-4 N-methylthiocyclohexylamide 
• 491-38-3 1-benzopyran-4(4H)-one 
• 50743-17-4 4-oxo-4H-1-benzopyran-3-carbonitrile 
• 1055424-80-0 5-benzo[1,3]dioxol-5-yl-3-cyclohexyl-2-methyl-2,3-dihydro-isoxazole-4-carboxylic acid ethyl ester 
• 1152672-21-3 (5-butyl-3-cyclohexyl-2-methyl-2,3-dihydro-isoxazol-4-yl)-phenyl-methanone 

Relevant academic research and scientific papers

One-Pot Sequential [3 + 3] Dipolar Cycloaddition of Aldehyde or Ketone and Hydroxylamine with Spirocyclopropyl Oxindole

A Sc(OTf)3-catalyzed highly diastereoselective one-pot sequential [3 + 3] dipolar cycloaddition reaction of aldehyde or ketone, N-alkyl hydroxylamine, and spirocyclopropyl oxindole is developed, allowing facile construction of spirocyclic oxind

SYNTHESIS OF THIOAMIDES FROM ALDONITRONES UTILIZING THIOCARBONYL TRANSFER REAGENTS

The reaction of 1,1'-thiocarbonyldiimidazole and 1,1'-thiocarbonylbis(1,2,4-triazole) with several aldonitrones has been found to afford thioamides in good yield.The effect of solvent polarity and base is discussed.

(3 + 3) Cycloaddition of Oxyallyl Cations with Nitrones: Diastereoselective Access to 1,2-Oxazinanes

Oxyallyl cations are prepared in situ from readily available α-tosyloxy ketones and act as transient electrophilic partners in (3 + 3) cycloaddition with nitrones. Under mild conditions, this method provides a chemoselective and diastereoselective route t

A torquoselective extrusion of isoxazoline N-oxides. Application to the synthesis of aryl vinyl and divinyl ketones for Nazarov cyclization

A mild, convenient reaction sequence for the synthesis of Nazarov cyclization substrates is described. The [3+2] dipolar cycloaddition of a nitrone and an electron-deficient alkyne gives an isolable isoxazoline intermediate, which upon oxidation undergoes stereoselective extrusion of nitrosomethane to give aryl vinyl or divinyl ketones.

Synthesis of functionalized sulfonamides via 1,3-dipolar cycloaddition of pentafluorophenyl vinylsulfonate

(Matrix presented) An efficient intermolecular 1,3-dipolar cycloaddition of a variety of nitrones to pentafluorophenyl (PFP) vinylsulfonate is described. The transformation produces stable "reversed" cycloadducts of unprecedented stereo- and regioselectiv

Studies on chromone derivatives: regioselective 1,3-dipolar and 1,4-cycloaddition reactions of 3-cyano-4H-1-benzopyran-4-thione

1,3-Dipolar cycloaddition reactions of 3-cyano-4H-1-benzopyran-4-thione 1 with nitrilimines 3, nitrile oxides 7 and aldonitrones 8 yielded regioselective cycloadducts involving the thione function.In the latter two classes, the unstable cycloadducts fragmented to yield 3-cyanochromone 11 and isothiocyanate 12 or thioamide 13, respectively.In contrast, dienamines 14 preferred to react at the carbon-carbon double bond in a 1,4-cycloaddition yielding xanthione (9H-xanthene-9-thione) 16 by elimination of HCN and the amine moiety.Keywords: 1,3-dipolar cycloaddition / 1,4-cycloaddition / 4H-1-benzopyran-4-thione / nitrilimine / nitrile oxide / nitrone

SOME NOVEL ASPECTS OF REGIOSELECTIVITY IN 1,3 DIPOLAR CYCLOADDITIONS OF 4H-1-BENZOPYRAN-4-THIONE

4H-1-Benzopyran-4-thione (1) reacted smoothly with nitrilimines (3a-e) to afford regioselective cycloadducts (4a-e) in good yields.In contrast,benzonitrile oxide (6) and aldonitrones (7a-d) reacted preferentially at the thione function.The unstable cycloadduct (8) or (9) ruptured to give as isolable products chromone (10) and phenyl isothiocyanate (11) and the thioamides (12a-d).This indirectly proves the site of attack of the dipole at the thione group.

Preparation of Vicinal N-Alkylamino Alcohols via Acylation-Rearrangement of Nitrones Followed by Hydride Reduction

Acylation-rearrangement of N-tert-butyl and N-cyclohexyl nitrones of cyclohexanecarboxaldehyde (1), n-butyraldehyde, isobutyraldehyde, 3-cyclohexenecarboxaldehyde, and α-methylpropionaldehyde gave α-pivaloyloxy imines, which underwent reduction with lithi

Utilization of thiocarbonyl transfer reagents. Preparation of thioamides, mercapto esters, and thiapyran derivatives

The reaction of 1,1'-thiocarbonyldiimidazole and 1,1'-thiocarbonylbis(1,2,4-triazole) with several aldonitrones has been found to afford thioamides in good yield.Several 1,1'-thiocarbonylbisazoles, which have been shown to undergo Diels-Alder additions wi

A CONVENIENT SYNTHESIS OF NITRONES BY N-ALKYLATION OF O-TRIMETHYLSILYLOXIMES

Aldoxime and ketoxime-O-trimethylsilyl ethers can be alkylated with trialkyl-oxonium tetrafluoroborates and alkyl triflates at or below room temperature to produce nitrones in good yields.