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1035805-54-9

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1035805-54-9 Usage

General Description

2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-Methyl- is a chemical compound with the molecular formula C9H9NOF. It is a derivative of indole, which is a heterocyclic organic compound. The presence of a fluoro group and a methyl group in this compound gives it unique properties and potential applications in various fields such as pharmaceuticals and agrochemicals. 2H-Indol-2-one, 5-fluoro-1,3-dihydro-3-Methyl- may have biological activities and could be used as a precursor in the synthesis of other organic compounds. Its structure and properties make it a subject of interest for researchers in the field of organic chemistry and drug discovery.

Check Digit Verification of cas no

The CAS Registry Mumber 1035805-54-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,5,8,0 and 5 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1035805-54:
(9*1)+(8*0)+(7*3)+(6*5)+(5*8)+(4*0)+(3*5)+(2*5)+(1*4)=129
129 % 10 = 9
So 1035805-54-9 is a valid CAS Registry Number.

1035805-54-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-fluoro-3-methylindolin-2-one

1.2 Other means of identification

Product number -
Other names 5-FLUORO-1,3-DIHYDRO-3-METHYL-2H-INDOL-2-ONE

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1035805-54-9 SDS

1035805-54-9Relevant articles and documents

Rapid Oxidation Indoles into 2-Oxindoles Mediated by PIFA in Combination with n-Bu4NCl ? H2O

Liang, Peng,Zhao, Hang,Zhou, Tingting,Zeng, Kaiyun,Jiao, Wei,Pan, Yang,Liu, Yazhou,Fang, Dongmei,Ma, Xiaofeng,Shao, Huawu

supporting information, p. 3532 - 3538 (2021/06/09)

We report the development of a rapid approach for directly converting indoles into 2-oxindoles promoted by HOCl formed in situ from the combination of (bis(trifluoroacetoxy) iodo)benzene (PIFA) and n-Bu4NCl ? H2O. The procedure is widely functional group tolerant and provides 2-oxindoles in up to 95% yield within 5 min. The potential applications of the developed methodology are demonstrated by the gram-scale preparation of 3-methyl-2-oxindole (11 a), the one-pot two-step syntheses of spiro-oxindoles 26 a and 26 b, and the formal synthesis of (-)-folicanthine (2). (Figure presented.).

Preparation method of 3-substituted oxidized indole and derivative

-

Paragraph 0193; 0194; 0195; 0196, (2018/06/26)

The invention belongs to the technical field of organic chemistry and pharmaceutical chemistry and particularly relates to a method of preparing 3-substituted oxidized indole and a derivative. In themethod, with a 3-substituted indole derivative as a raw material and one or more of a tetrabutyl ammonium halide compound/sodium chloride/sodium iodide/potassium iodide as additives, and one or more of dichloromethane/1,2-dichloroethane/tetrahydrofurane/methylbenzene/1,4-dioxane/ethyl acetate/methanol are added as solvents; then one or more of [bis(trifluoroacetoxyl)iodine]benzene/iodosobenzene diacetate are added as oxidants in order to carry out a reaction with reaction temperature being controlled, thus producing the 3-substituted oxidized indole derivative. The method has gentle reaction conditions, simple operations, short reaction time and high yield, and is free of a metal catalyst and is environment-friendly.

Magnesium-Catalyzed Electrophilic Trifluoromethylation: Facile Access to All-Carbon Quaternary Centers in Oxindoles

Katayev, Dmitry,Kajita, Harutake,Togni, Antonio

supporting information, p. 8353 - 8357 (2017/06/28)

The first example of a magnesium-catalyzed direct trifluoromethylation of 3-substituted oxindoles using an electrophilic hypervalent iodine reagent is reported. The reaction proceeds under unprecedented mild conditions leading to the formation of an all-carbon quaternary center in oxindoles in high chemical yield and demonstrates excellent functional group tolerance. In addition to trifluoromethyl, other perfluoroalkyl groups can be introduced with similar level of efficacy. Mechanistic investigations are consistent with the involvement of a radical pathway. The chemical versatility of the obtained products is further illustrated through their conversion in situ into valuable organofluorine building blocks, making the protocol more widely applicable.

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