1035806-96-2

Basic information

• Product Name: (2-methyl-indol-1-yl)-acetic acid ethyl ester
• Synonyms: (2-methyl-indol-1-yl)-acetic acid ethyl ester
• CAS NO: 1035806-96-2
• Molecular Formula: C13H15NO2
• Molecular Weight: 217
• Mol File: 1035806-96-2.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2-methyl-indol-1-yl)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2-methyl-indol-1-yl)-acetic acid ethyl ester(1035806-96-2)
• EPA Substance Registry System: (2-methyl-indol-1-yl)-acetic acid ethyl ester(1035806-96-2)

Safety Data

• Hazardous Substances Data: 1035806-96-2(Hazardous Substances Data)

Usage

General Description

"(2-methyl-indol-1-yl)-acetic acid ethyl ester" is a chemical compound with the formula C12H13NO2. It is an ethyl ester derivative of (2-methyl-indol-1-yl)-acetic acid, which is a derivative of indole, a common chemical structure found in many natural products and pharmaceuticals. (2-methyl-indol-1-yl)-acetic acid ethyl ester has potential applications in the pharmaceutical industry as a building block for the synthesis of various drugs and biologically active molecules. Its specific properties and uses are still being studied, but it shows promise as a versatile intermediate in organic synthesis. Further research and development of this compound may lead to the discovery of new therapeutic agents or industrial applications.

Upstream product

• 95-20-5 2-methyl-1H-indole 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 86704-55-4 2-(2-methyl-1H-indol-1-yl)acetic acid 

Relevant articles and documents

Polymer supported bases in solution-phase synthesis. 2. A convenient method for N-alkylation reactions of weakly acidic heterocycles

A convenient solution-phase method for N-alkylation reactions of weakly acidic heterocycles employing polymer supported super base PBEMP is described. By using this method, multiple-step and chemoselective N- alkylation sequences can be carried out in a one-pot process.

NEW CRTh2 ANTAGONISTS

The present invention relates to compounds of formula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by CRTh2 antagonist activity.

Indanediones-1,3 VIII. Hydroxy-2 indolyl-2 indanediones-1,3, (indolyl-3 methylene)-2 indanediones-1,3 et derives: recherche d'une activite anti-inflammatoire

1,3-Indandiones VIII. 2-Hydroxy-2-indolyl-1,3-indandiones, 2-(indol-3-ylmethylene indandione and derivatives: search for anti-inflammatory activity.A series of 2-hydroxy-2-indolyl-1,3-indandiones, diversely substituted on the heterocycle were synthetized in order to study their anti-inflammatory activity.Catalytic hydrogenation gave 2,3-dihydroxy-1 indanones 6 and NaBH4 reduction of 3i led to the corresponding indanetriol 7i.Base-catalyzed isomerization of hydroxy-β-diketones 3 furnished 3-indololylcarbonyl phthalides 9.Only compound 3d exhibited a significant inhibition of mouse paw edema.Experimentation in the rat paw edema test confirmed the anti-inflammatory effect of 3d, but it was associated with an anti-coagulant activity. ω-Amino-alkylation of the indole nitrogen of 3d led to loss of anti-inflammatory activity.Introduction of a double bond between the indandione and indole nuclei, leading to 2-(indol-3-ylmethylene)-1,3 indandiones 12, proved ineffective in raising this activity. 2-hydroxy-2-indolyl-1,3-indandiones/ 2,3-dihydroxyindanones/ 1,2,3-indantriols/ 3-indolylcarbonyl-phthalides/ 2-(indol-3-ylmethylene)-1,3-indandiones/ anti-inflammatory activity/ anti-coagulant activity