1035808-32-2Relevant articles and documents
Small molecules that mimic the thiol-triggered alkylating properties seen in the natural product leinamycin
Chatterji, Tonika,Kizil, Murat,Keerthi, Kripa,Chowdhury, Goutam,Pospisil, Tomas,Gates, Kent S.
, p. 4996 - 4997 (2007/10/03)
Reaction of the antitumor agent leinamycin with cellular thiols results in conversion of the natural product to a DNA-alkylating episulfonium alkylating agent via an intriguing sequence of chemical reactions. To establish whether the chemistry first seen