10359-47-4Relevant academic research and scientific papers
Method for selective deuteration of benzyl-position carbon hydrogen bond of aromatic ring
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Paragraph 0133-0135, (2021/10/30)
The invention discloses a method for selective deuteration of benzyl-position carbon hydrogen bonds of aromatic rings. To the method, η is carried out on an aromatic ring by using a metal rhodium catalyst. 6 The coordination is activated so tha
Enantiomeric products formed via different mechanisms: asymmetric hydrogenation of an α,β-unsaturated carboxylic acid involving a Ru(CH3COO)2[(R)-binap] catalyst
Yoshimura, Masahiro,Ishibashi, Yoshitaka,Miyata, Kengo,Bessho, Yuhki,Tsukamoto, Masaki,Kitamura, Masato
, p. 11399 - 11409 (2008/03/13)
Hydrogenation of (Z)-3-phenyl-2-butenoic acid with a Ru(CH3COO)2[(R)-binap] (BINAP=2,2′-bis(diphenylphosphino)-1,1′-binaphthyl) catalyst in methanol gives (S)-3-phenyl-2-butanoic acid and its R enantiomer in a 97:3 (4 atm) to 94:6 (100 atm) ratio in quantitative yield. Both hydrogen gas and protic methanol participate in the saturation of the olefinic bond. Analysis of the products obtained using (Z)-3-phenyl-2-butenoic acid-3-13C and either H2, a 1:1 H2-D2 mixture, or D2 in CH3OD indicates that several catalytic cycles are operative, showing different reactivity and stereoselectivity. The major S enantiomer was formed primarily by the standard Ru monohydride mechanism, whereas the minor R isomer is produced via more complicated routes.
