1035904-56-3Relevant academic research and scientific papers
Silica-immobilized NHC-CuI complex: An efficient and reusable catalyst for A3-coupling (aldehyde-alkyne-amine) under solventless reaction conditions
Wang, Min,Li, Pinhua,Wang, Lei
, p. 2255 - 2261 (2008)
A novel silica-immobilized NHC-CuI complex was developed and used as a highly efficient catalyst in the three-component coupling reactions of aldehydes, alkynes and amines (A3-coupling). The reactions were applicable to aromatic and aliphatic aldehydes, alkynes and amines, and generated the corresponding propargylamines in good yields only in the presence of SiO2-NHC-CuI (2 mol-%) at room temp. under solvent-free reaction conditions. Moreover, the catalyst was quantitatively recovered from the reaction mixture by a simple filtration and reused for ten cycles with almost consistent activity. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
Highly efficient three-component (aldehyde-alkyne-amine) coupling reactions catalyzed by a reusable PS-supported NHC-Ag(I) under solvent-free reaction conditions
Li, Pinhua,Wang, Lei,Zhang, Yicheng,Wang, Min
scheme or table, p. 6650 - 6654 (2009/04/07)
The development of a highly efficient, polystyrene-supported NHC-Ag(I) catalyst for the three-component coupling reactions of aldehydes, alkynes, and amines (A3-coupling) was described. In the presence of PS-NHC-Ag(I) (2 mol %), the A3-reactions were carried out at room temperature under solvent-free reaction conditions and the corresponding propargylamines were generated in good to excellent yields. Furthermore, the catalyst could be reused at least 12 times without a significant loss of its catalytic activity.
