623-47-2

Basic information

• Product Name: Ethyl propiolate
• Synonyms: ACETYLENECARBOXYLIC ACID ETHYL ESTER;ETHYL PROPIOLATE;ETHYL ACETYLENECARBOXYLATE;EPL;(Ethoxycarbonyl)acetylene;2-Propynoic acid, ethyl ester;Ethyl 2-propynoate;Ethyl propynoate
• CAS NO: 623-47-2
• Molecular Formula: C₅H₆O₂
• Molecular Weight: 98.1
• EINECS: 210-795-8
• Product Categories: Acids and Derivatives;Miscellaneous;Acetylenes;Acetylenic Carboxylic Acids & Their Derivatives;Building Blocks;C2 to C5;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks
• Mol File: 623-47-2.mol
• Article Data: 20

Chemical Properties

• Melting Point: 9°C
• Boiling Point: 120 °C(lit.)
• Flash Point: 74 °F
• Appearance: Clear colorless to pale yellow/Liquid
• Density: 0.968 g/mL at 25 °C(lit.)
• Vapor Pressure: 15.5mmHg at 25°C
• Refractive Index: n20/D 1.412(lit.)
• Storage Temp.: 2-8°C
• Solubility: Miscible with alcohol.
• Water Solubility: miscible
• Merck: 14,3846
• BRN: 878250
• CAS DataBase Reference: Ethyl propiolate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl propiolate(623-47-2)
• EPA Substance Registry System: Ethyl propiolate(623-47-2)

Safety Data

• Hazard Codes: Xi,F
• Statements: 10-36/37/38-36-11
• Safety Statements: 26-36-37/39-16-33-29-24-23
• RIDADR: UN 3272 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: II
• Hazardous Substances Data: 623-47-2(Hazardous Substances Data)

Usage

Chemical Description

Ethyl propiolate is an ester with the formula C5H6O2, and pyridine is a basic heterocyclic organic compound with the formula C5H5N.

Chemical Properties

Ethyl propiolate is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.

Uses

Different sources of media describe the Uses of 623-47-2 differently. You can refer to the following data:
1. Halogenated derivatives were used as substrates for direct, asymmetric alkynylation of cyclic ?-ketoesters using chiral phase-transfer catalysts. Also employed in a one-pot , four-component synthesis of benzene-1,2,3,5-tetracarboxylates promoted by Ph3P.
2. In organic synthesis; peptide coupling reagent.
3. Ethyl propiolate is used as a precursor in the preparation of substituted anthraquinones and pyrazolo[1,5-a]pyridine, which exhibits anti-inflammatory activity. Further, it is employed in the synthesis of benzene-1,2,3,5-tetracarboxylates promoted by triphenylphosphine. Its halogenated derivatives are used as a substrate for direct, asymmetric alkynylation of cyclic beta-ketoesters using chiral phase-transfer catalysts.

Definition

ChEBI: Ethyl propiolate is the ethyl ester of prop-2-ynoic acid. It is a ynoate ester, a terminal acetylenic compound and an ethyl ester.

Hazard

Flammable; lachrymator.

InChI:InChI=1/C5H6O2/c1-3-5(6)7-4-2/h1H,4H2,2H3

Synthetic route

ethanol (64-17-5) + Propiolic acid (471-25-0) → propynoic acid ethyl ester (623-47-2)

Conditions	Yield
With sulfuric acid; trimethyl orthoformate In dichloromethane at 40℃; for 24h; Reagent/catalyst;	86.7%
boron trifluoride diethyl etherate 1.) reflux, 1.5 h; 2.) rt., 4 h.;	60%
With sulfuric acid for 24h; Reflux;	36%

Ethyl half ester of acetylenedicarboxylic acid (38391-86-5) + toluene (108-88-3) → propynoic acid ethyl ester (623-47-2)

Conditions	Yield
at 100℃; Zeitlicher Verlauf der thermischen Zersetzung;

(E)-4-(Triphenyl-λ5-phosphanylidene)-pent-2-enedioic acid diethyl ester (119930-16-4) → ethyl (triphenylphosphoranylidene)acetate (1099-45-2) + propynoic acid ethyl ester (623-47-2)

Conditions	Yield
equil. react.;

Ethyl half ester of acetylenedicarboxylic acid (38391-86-5) + water (7732-18-5) → propynoic acid ethyl ester (623-47-2)

Conditions	Yield
at 100℃; Zeitlicher Verlauf der thermischen Zersetzung;

Mesitol (527-60-6) + chloroformic acid ethyl ester (541-41-3) + Propiolic acid (471-25-0) → Trifluoressigsaeure-(2,4,6-trimethyl-phenylester) (1737-55-9) + propynoic acid ethyl ester (623-47-2)

Conditions	Yield
Stage #1: Propiolic acid With lithium hydride In tetrahydrofuran at 20℃; for 18h; Metallation; Stage #2: chloroformic acid ethyl ester In tetrahydrofuran at -10 - 20℃; Acylation; Stage #3: Mesitol In tetrahydrofuran at 20 - 45℃; Substitution;

chloroformic acid ethyl ester (541-41-3) + sodium 2,4,6-trimethylphenoxide (51114-00-2) + Propiolic acid (471-25-0) → Trifluoressigsaeure-(2,4,6-trimethyl-phenylester) (1737-55-9) + carbonic acid ethyl ester 2,4,6-trimethyl-phenyl ester + (E)-3-(2,4,6-Trimethyl-phenoxy)-acrylic acid 2,4,6-trimethyl-phenyl ester + propynoic acid ethyl ester (623-47-2)

Conditions	Yield
Stage #1: Propiolic acid With lithium hydride In tetrahydrofuran at 20℃; for 18h; Metallation; Stage #2: chloroformic acid ethyl ester In tetrahydrofuran at -10 - 20℃; Acylation; Stage #3: sodium 2,4,6-trimethylphenoxide In tetrahydrofuran at 20 - 45℃; Substitution;

methyl propargyl alcohol (764-01-2) + diethylazodicarboxylate (1972-28-7) + phenol (108-95-2) → but-2-ynyloxybenzene (13610-09-8) + propynoic acid ethyl ester (623-47-2)

Conditions	Yield
With triphenylphosphine In tetrahydrofuran; benzene	A 2.18 g (70%) B n/a

propargyl alcohol (107-19-7) + diethylazodicarboxylate (1972-28-7) + 5-bromo-2-[(4-hydroxy-benzenesulfonyl)-methyl-amino]-3-methyl-benzoic acid methyl ester (287108-60-5) → propynoic acid ethyl ester (623-47-2) + 5-bromo-3-methyl-2-[methyl-(4-prop-2-ynyloxy-benzenesulfonyl)-amino]-benzoic acid methyl ester (287108-61-6)

Conditions	Yield
With triphenylphosphine In tetrahydrofuran; benzene	A n/a B 0.389 g (71%)

(hydrotris(3,5-diisopropylpyrazolyl)borato)CoCCC(O)OCH2CH3 (461695-81-8) + water (7732-18-5) → [Co(hydrotris(3,5-diisopropyl-1-pyrazolyl)borate)]2(OH)2 + propynoic acid ethyl ester (623-47-2)

Conditions	Yield
In not given

chloroformic acid ethyl ester (541-41-3) + acetylene (74-86-2) → propynoic acid ethyl ester (623-47-2)

Conditions	Yield
Stage #1: acetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.25h; Inert atmosphere; Stage #2: chloroformic acid ethyl ester In tetrahydrofuran; hexane at -78℃; for 8h; Inert atmosphere;
Stage #1: acetylene With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.5h; Inert atmosphere; Stage #2: chloroformic acid ethyl ester In tetrahydrofuran; hexane at -78 - 20℃; for 1.5h; Inert atmosphere;

glyoxylic acid ethyl ester (924-44-7) → propynoic acid ethyl ester (623-47-2)

Conditions	Yield
With C7H13N2O4P; potassium carbonate In methanol at 20℃; Inert atmosphere;

piperidine (110-89-4) + propynoic acid ethyl ester (623-47-2) → ethyl (E)-3-(piperidin-1-yl)acrylate (81239-00-1)

Conditions	Yield
at 20℃; for 0.0333333h; Michael addition;	100%
With water at 20℃; for 0.0833333h; optical yield given as %de; stereoselective reaction;	96%
With benzene

propynoic acid ethyl ester (623-47-2) → 2-propynamide (7341-96-0)

Conditions	Yield
With ammonia at -78 - 20℃; for 5h;	100%
With ammonia at -55℃; for 9h;	83%
With ammonium hydroxide at -10℃; for 1h; Inert atmosphere;	74%

pyrrolidine (123-75-1) + propynoic acid ethyl ester (623-47-2) → ethyl (E)-3-(pyrrolidin-1-yl)acrylate (65651-80-1)

Conditions	Yield
In toluene at 20℃; for 16h;	100%
With water In neat (no solvent) at 20℃; for 0.166667h; Michael Addition; Sealed tube; Green chemistry; stereoselective reaction;	99%
With water at 20℃; for 0.0833333h; optical yield given as %de; stereoselective reaction;	91%

morpholine (110-91-8) + propynoic acid ethyl ester (623-47-2) → ethyl (E)-3-(morpholin-4-yl)acrylate (81239-01-2)

Conditions	Yield
at 20℃; for 0.0333333h; Michael addition;	100%
With water In neat (no solvent) at 20℃; for 0.166667h; Michael Addition; Sealed tube; Green chemistry; stereoselective reaction;	99%
With water at 20℃; for 0.0833333h; optical yield given as %de; stereoselective reaction;	94%

2-methoxy-phenylamine (90-04-0) + propynoic acid ethyl ester (623-47-2) → ethyl 3-<(2-methoxyphenyl)amino>acrylate (115607-78-8)

Conditions	Yield
In ethanol for 3h; Heating;	100%

ethanol (64-17-5) + propynoic acid ethyl ester (623-47-2) → ethyl 3,3-diethoxypropanoate (10601-80-6)

Conditions	Yield
With potassium for 12h;	100%
With copper(II) sulfate for 24h; Heating / reflux;	37%

1-Azidoadamantane (24886-73-5) + propynoic acid ethyl ester (623-47-2) → 1-(1-adamantyl)-4-(ethyoxycarbonyl)-1H-1,2,3-triazole (76599-43-4)

Conditions	Yield
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; tris[(1-benzyl-1H-1,2,3-triazol-4yl)methyl]amine In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;	100%
With 2,6-dimethylpyridine In water at 20℃; for 8h; Huisgen 1,3-dipolar cycloaddition; regioselective reaction;	96%
With C22H28CuIN2 In neat (no solvent) at 20℃; for 72h;	81%
In toluene at 110℃; for 50h;	77%

ethyl N-hydroxybenzimidate (7340-17-2) + propynoic acid ethyl ester (623-47-2) → ethyl N-<(2'-ethoxycarbonylvinyl)oxy>benzimidate (139172-68-2, 144946-63-4)

Conditions	Yield
With triethylamine for 0.166667h; Ambient temperature;	100%

C15H17N3O4 (135907-85-6) + propynoic acid ethyl ester (623-47-2) → C20H23N3O6 (135907-91-4)

Conditions	Yield
In acetonitrile for 24h; Ambient temperature;	100%

propynoic acid ethyl ester (623-47-2) → ethyl (Z)-3-iodopropenoate (31930-36-6)

Conditions	Yield
With acetic acid; sodium iodide at 70℃; for 16h; Inert atmosphere;	100%
With acetic acid; sodium iodide at 70℃; for 16h; Inert atmosphere;	99%
With acetic acid; sodium iodide	98%

phosphonic acid diethyl ester (762-04-9) + propynoic acid ethyl ester (623-47-2) → ethyl β,β-bis(diethoxyphosphoryl)propionate (1112-29-4)

Conditions	Yield
With aluminum oxide; potassium hydroxide In dichloromethane at 20℃; for 0.0833333h;	100%
With sodium hexamethyldisilazane 1) THF, -50 deg C, 15 min; 2) THF, -50 deg C, 10 min; Yield given. Multistep reaction;
With aluminum oxide; potassium hydroxide at 20℃; for 0.0833333h; Yield given;

diazomethane (186581-53-3, 908094-01-9) + propynoic acid ethyl ester (623-47-2) → ethyl 1H-pyrazole-3-carboxylate (5932-27-4)

Conditions	Yield
In diethyl ether Ambient temperature;	100%

(S)-2-[(4-methoxybenzyloxy)methyl]oxirane (80910-01-6, 108836-41-5, 134733-19-0, 144069-33-0) + propynoic acid ethyl ester (623-47-2) → ethyl (5S)-5-hydroxy-6-(4-methoxybenzyloxy)hex-2-ynoate (302554-85-4)

Conditions	Yield
With n-butyllithium; boron trifluoride diethyl etherate In tetrahydrofuran at -78℃; for 0.5h; Ring cleavage;	100%
Stage #1: propynoic acid ethyl ester With n-butyllithium In tetrahydrofuran; hexane at -90℃; for 0.333333h; Stage #2: (S)-2-[(4-methoxybenzyloxy)methyl]oxirane With boron trifluoride diethyl etherate In tetrahydrofuran; hexane at -90 - 0℃;	100%

propynoic acid ethyl ester (623-47-2) + 1-[(2R,3S,6R,7S)-3-Hydroxy-6-(4-methoxy-benzyloxy)-7-(4-methoxy-benzyloxymethyl)-2-methyl-oxepan-2-yl]-propan-2-one (370884-58-5) → (E)-3-[(2R,3S,6R,7S)-6-(4-Methoxy-benzyloxy)-7-(4-methoxy-benzyloxymethyl)-2-methyl-2-(2-oxo-propyl)-oxepan-3-yloxy]-acrylic acid ethyl ester (370884-60-9)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane at 20℃;	100%
With 4-methyl-morpholine In dichloromethane at 30℃; for 16h;	100%

propynoic acid ethyl ester (623-47-2) + 1-(benzyloxy)-3-(phenyltellanyl)propan-2-ol (396714-80-0) → (E)-3-(1-benzyloxymethyl-2-phenyltellurenyl-ethoxy)-acrylic acid ethyl ester (396714-84-4)

Conditions	Yield
With 4-methyl-morpholine In dichloromethane at 20℃; hetero-Michael addition reaction;	100%
With 4-methyl-morpholine In dichloromethane at 20℃; hetero-Michael addition;	80%

1-Phenyl-3-buten-1-ol (80735-94-0) + propynoic acid ethyl ester (623-47-2) → ethyl (E)-3-(1-phenyl-3-buten-1-yl)oxy-2-propenoate

Conditions	Yield
Stage #1: propynoic acid ethyl ester With triethylamine In diethyl ether for 0.25h; Inert atmosphere; Stage #2: 1-Phenyl-3-buten-1-ol In diethyl ether for 28h; Inert atmosphere;	100%
Stage #1: propynoic acid ethyl ester With triethylamine In diethyl ether at 20℃; for 0.166667h; Stage #2: 1-Phenyl-3-buten-1-ol In diethyl ether at 20℃; for 48h;	97%

1-benzylidene-4,4-dimethyl-3-oxopyrazolidin-1-ium-2-ide (606123-85-7) + propynoic acid ethyl ester (623-47-2) → 6,6-dimethyl-5-oxo-1-phenyl-6,7-dihydro-1H,5H-pyrazolo[1,2-a]pyrazole-2-carboxylic acid ethyl ester

Conditions	Yield
With copper(l) iodide; phosphaferrocene-4-(S)-i-Pr-oxazoline; N-Methyldicyclohexylamine In dichloromethane at 20℃; for 20h;	100%

2-(dimethylamino)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde (111680-71-8) + propynoic acid ethyl ester (623-47-2) + phenylglycine methyl ester (24461-61-8, 26682-99-5, 37760-98-8, 6591-61-3) → C15H15NO4

Conditions	Yield
Stage #1: 2-(dimethylamino)-4-oxo-4H-pyrido<1,2-a>pyrimidine-3-carbaldehyde; phenylglycine methyl ester In toluene at 85℃; for 1h; Stage #2: propynoic acid ethyl ester In toluene at 85℃; for 3.5h; Stage #3: With pyridinium p-toluenesulfonate In toluene Further stages.;	100%

2-methoxy-phenylamine (90-04-0) + propynoic acid ethyl ester (623-47-2) → ethyl 3-(2-methoxyphenylamino)acrylate (142781-90-6)

Conditions	Yield
In ethanol	100%

bis(pinacol)diborane (73183-34-3) + propynoic acid ethyl ester (623-47-2) → ethyl (2E)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acrylate (1009307-13-4)

Conditions	Yield
Stage #1: bis(pinacol)diborane With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; copper(l) chloride; sodium t-butanolate In tetrahydrofuran at 20℃; for 0.166667h; Schlenk technique; Inert atmosphere; Stage #2: propynoic acid ethyl ester In tetrahydrofuran; methanol Sealed tube; Schlenk technique; Inert atmosphere;	100%
Stage #1: bis(pinacol)diborane With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; copper(l) chloride; sodium t-butanolate In tetrahydrofuran at 25℃; for 0.166667h; Schlenk technique; Inert atmosphere; Stage #2: propynoic acid ethyl ester In tetrahydrofuran; methanol at 25℃; Schlenk technique; Inert atmosphere; Sealed tube;	95%
Stage #1: bis(pinacol)diborane With 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; copper(l) chloride; sodium t-butanolate In tetrahydrofuran at 25℃; for 0.166667h; Inert atmosphere; Stage #2: propynoic acid ethyl ester In tetrahydrofuran; methanol at 25℃; for 11.4h; Inert atmosphere;	85.3%

C13H16O4 (1021700-66-2) + propynoic acid ethyl ester (623-47-2) → C18H22O6

Conditions	Yield
With 4-methyl-morpholine at 20℃; for 12h; Michael addition; Inert atmosphere;	100%

trans-Crotonaldehyde (123-73-9) + propynoic acid ethyl ester (623-47-2) → C9H12O3

Conditions	Yield
Stage #1: propynoic acid ethyl ester With n-butyllithium; diisopropylamine In tetrahydrofuran; hexane at -78℃; for 0.5h; Stage #2: trans-Crotonaldehyde In tetrahydrofuran; hexane at -78℃; for 1.5h;	100%

2-azidoethanol (1517-05-1) + propynoic acid ethyl ester (623-47-2) → 1-(2-hydroxyethyl)-4-ethoxycarbonyl-1H-1,2,3-triazole

Conditions	Yield
With supported Cu(I) bis-2-pyridiylamine functionalized silica Si-BPA*Cu+ In water; tert-butyl alcohol for 1h; Microwave irradiation; regiospecific reaction;	100%
With copper(II) loaded mesoporous SBA-15 In dichloromethane at 20℃; Huisgen Cycloaddition; regioselective reaction;	64%

pyrrolidine (123-75-1) + propynoic acid ethyl ester (623-47-2) → ethyl-3-(pyrrolidin-1-yl)prop-2-enoate (53927-12-1)

Conditions	Yield
In tetrahydrofuran at 10 - 25℃; for 1h;	100%
In acetonitrile at 20℃; for 10h;	98%
In acetonitrile at 20℃; Inert atmosphere;
In acetonitrile at 20℃;	9.47 g

N-benzyl-α-diazoacetamide (105310-97-2) + propynoic acid ethyl ester (623-47-2) → ethyl 5-(benzylcarbamoyl)-1H-pyrazole-3-carboxylate

Conditions	Yield
In water; acetonitrile at 22℃; under 760.051 Torr;	100%

C31H36Cl2O8S + propynoic acid ethyl ester (623-47-2) → C36H42Cl2O10S

Conditions	Yield
With 4-methyl-morpholine In dichloromethane at 0 - 20℃; for 4h;	100%

C10H16N2O4 (95239-02-4) + 2-(1-methyl-1H-indol-3-yl)ethylamine (7518-21-0) + propynoic acid ethyl ester (623-47-2) → 4-ethyl 3-methyl 2-methyl-1-[2-(1-methyl-1H-indol-3-yl)ethyl]-1H-pyrrole-3,4-dicarboxylate

Conditions	Yield
Stage #1: 2-(1-methyl-1H-indol-3-yl)ethylamine; propynoic acid ethyl ester In dichloromethane at 20℃; Stage #2: C10H16N2O4 In dichloromethane; toluene for 2h; Reflux; Stage #3: With trifluoroacetic acid In dichloromethane; toluene Reflux;	100%

propynoic acid ethyl ester (623-47-2) → triethyl benzene-1,3,5-tricarboxylate (4105-92-4)

Conditions	Yield
With chloro-trimethyl-silane In butan-1-ol; benzene at 40℃; for 8h; regioselective reaction;	99.1%
With ClO4 In methanol Ambient temperature;	87%
With piperazine; LACTIC ACID In N,N-dimethyl-formamide at 90℃; for 12h;	78%

propynoic acid ethyl ester (623-47-2) → (Z)-ethyl 2,3-dibromoprop-2-enoate (26631-66-3)

Conditions	Yield
With bromine In tetrachloromethane at 70℃; for 0.5h;	99%
With bromine In tetrachloromethane at 70℃; for 2.5h;	90%
With bromine In tetrachloromethane at 70℃; for 1.5h;	83%
With bromine In tetrachloromethane Irradiation;
With bromine In tetrachloromethane at 70℃; for 1.5h; Yield given;

Phenyl azide (622-37-7) + propynoic acid ethyl ester (623-47-2) → 1-phenyl-1H-[1,2,3]triazole-4-carboxylic acid ethyl ester (4915-97-3)

Conditions	Yield
With C30H23Cl2N7O4Ru(1+)*Cl(1-) In water at 23℃; for 0.0666667h; Huisgen Cycloaddition; Sonication; Green chemistry; regioselective reaction;	99%
In ethanol for 20h; Heating;	95%
With copper(I) oxide In water at 25℃; for 0.0833333h; Inert atmosphere;	95%

Upstream product

• 107-19-7 propargyl alcohol 
• 1972-28-7 diethylazodicarboxylate 
• 287108-60-5 5-bromo-2-[(4-hydroxy-benzenesulfonyl)-methyl-amino]-3-methyl-benzoic acid methyl ester 
• 541-41-3 chloroformic acid ethyl ester 
• 51114-00-2 sodium 2,4,6-trimethylphenoxide 
• 471-25-0 Propiolic acid 
• 527-60-6 Mesitol 
• 38391-86-5 Ethyl half ester of acetylenedicarboxylic acid 
• 7732-18-5 water 
• 119930-16-4 (E)-4-(Triphenyl-λ⁵-phosphanylidene)-pent-2-enedioic acid diethyl ester 
• 64-17-5 ethanol 
• 108-88-3 toluene 
• 924-44-7 glyoxylic acid ethyl ester 
• 74-86-2 acetylene 

Downstream Products

• 100520-15-8 4,6,6-trimethyl-cyclohexa-1,3-dienecarboxylic acid ethyl ester 
• 14149-36-1 3-ethyl-3-phenyl-3H-pyridine-2,6-dione 
• 1821-12-1 4-Phenylbutyric acid 
• 10601-80-6 ethyl 3,3-diethoxypropanoate 
• 42103-65-1 3c-phenoxy-acrylic acid 
• 3588-17-8 (2E,4E)-2,4-hexadienedioic acid 
• 110-15-6 succinic acid 
• 7341-96-0 2-propynamide 
• 17649-36-4 3-phenylthiazolo[3,2-a]pyrimidin-7-one 
• 18352-41-5 (E)-3-[Bis-(2-chloro-ethyl)-amino]-acrylic acid ethyl ester 
• 16205-90-6 ethyl 2-hexynoate 
• 67048-96-8 Ethyl-3-(p-chlorphenyl)-isothiazol-5-carboxylat 
• 67048-37-7 ethyl 3-(4-chlorophenyl)-1,2-thiazole-4-carboxylate 
• 64766-03-6 3t-[2-ethoxy-3-(4-nitro-phenyl)-5-phenyl-2,3-dihydro-[1,3,4]oxadiazol-2-yl]-acrylic acid ethyl ester 

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