103593-53-9

Upstream product

• 93379-12-5 (S)-2-O-(1-ethoxyethyl)-N,N-dimethyllactamide 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 124-63-0 methanesulfonyl chloride 
• 111197-87-6 (S)-2-hydroxy-1-(4-methylphenyl)-1-propanone 2,2-dimethyl-trimethylene acetal 
• 111199-11-2 (S)-2-methoxymethoxy-1-(4-methylphenyl)-1-propanone 
• 111197-79-6 (S)-2-hydroxy-1-(4-methylphenyl)-1-propanone 

Downstream Products

• 103593-62-0 5,5-Dimethyl-2-((S)-1-p-tolyl-ethyl)-[1,3]dioxane 

Relevant academic research and scientific papers

A General Synthetic Method of Chiral 2-Arylalkanoic Esters via Thermal 1,2-Rearrangement

(S)-1-Aryl-2-sulfonyloxy-1-alkanone acetals, prepared from natural ethyl (S)-lactate or (S)-valine (chiral sources) by the use of a Grignard reaction, were rearranged under hydrolytic conditions in the presence of a base to give (S)-2-arylalkanoic esters which in general, showed much higher pharmacological activities than their antipodes.

A NOVEL SYNTHETIC METHOD OF OPTICALLY PURE α-SUBSTITUTED ALDEHYDE ACETALS BY USE OF REDUCTIVE 1,2-REARRANGEMENT

A new reductive 1,2-rearrangement of aryl (or alkenyl) groups of α-sulfonyloxy acetals to give the title compounds was developed by using the combination of i-Bu2AlH and Et3Al, and this method was applied to the synthesis of optically pure (R)-(-)-α-curcu