103602-79-5

Basic information

• Product Name: N-(3-oxo-3,4,4a,5,6,7-hexahydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-9-yl)acetamide
• CAS NO: 103602-79-5
• Molecular Formula: C₁₅H₁₇N₃O₂
• Molecular Weight: 271.3144
• Mol File: 103602-79-5.mol
• Article Data: 1

Chemical Properties

• Density: 1.38g/cm³
• Refractive Index: 1.685
• CAS DataBase Reference: N-(3-oxo-3,4,4a,5,6,7-hexahydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-9-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-oxo-3,4,4a,5,6,7-hexahydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-9-yl)acetamide(103602-79-5)
• EPA Substance Registry System: N-(3-oxo-3,4,4a,5,6,7-hexahydro-2H-benzo[6,7]cyclohepta[1,2-c]pyridazin-9-yl)acetamide(103602-79-5)

Safety Data

• Hazardous Substances Data: 103602-79-5(Hazardous Substances Data)

Upstream product

• 95207-74-2 2-(N-acetyl)amino-6,7,8,9-tetrahydrobenzo-cyclohepten-5-one 
• 103602-86-4 [2-Acetylamino-5-oxo-5,7,8,9-tetrahydro-benzocyclohepten-(6Z)-ylidene]-acetic acid 
• 121866-01-1 (2-Acetylamino-5-oxo-6,7,8,9-tetrahydro-5H-benzocyclohepten-6-yl)-acetic acid 

Downstream Products

• 103603-08-3 9-amino-2,4,4a,5,6,7-hexahydrobenzo[6,7]cyclohepta-[1,2-c]pyridazin-3-one 

Relevant articles and documents

Synthesis and biological evaluation of subsitituted benzo[h]cinnolinones and 3H-benzo[6,7]cyclohepta[1,2-c]pyridazinones: Higher homologues of the antihypertensive and antithrombotic 5H-indeno[1,2-c]pyridazinones

Several substituted benzo[h]cinnolinones 3 and 3H-benzo[6,7]cyclohepta[1,2-c]pyridazinones 4, which were designed as less rigid congeners of 5H-indeno[1,2-c]pyridazinones 2, were synthesized and tested as antihypertensive, inotropic, antithrombotic, antiinflammatory, and antiulcer agents. While the seven-membered ring derivatives displayed only antithrombotic properties, which were comparable to that of acetylsalicylic acid, most of the benzo[h]cinnolinones exhibited significant antihypertensive, inotropic, and antithrombotic properties. In this respect, the 8-amino (3b) and 8-acetylamino (3c) together with the 4,4a-dehydro analogue of 3c were found to possess the most potent and long-lasting antihypetensive activity. In particular, the dextro isomer of 3c was more active than the racemic form, with lower tachycadiac effects. Unlike the lower homologues 2, none of the compounds showed significant antiinflammatory or antiulcer activity.