103602-95-5

Basic information

• Product Name: Brn 6572492
• Synonyms: Brn 6572492
• CAS NO: 103602-95-5
• Molecular Formula: C14H15 N3 O2
• Mol File: 103602-95-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Brn 6572492(CAS DataBase Reference)
• NIST Chemistry Reference: Brn 6572492(103602-95-5)
• EPA Substance Registry System: Brn 6572492(103602-95-5)

Safety Data

• Hazardous Substances Data: 103602-95-5(Hazardous Substances Data)

Upstream product

• 103422-64-6 (6-acetamido-1-oxo-1,2,3,4-tetrahydronaphth-2-yl)acetonitrile 
• 103422-89-5 6-(acetylamino)-1,2,3,4-tetrahydro-N,N,N-trimethyl-1-oxo-2-naphthalenemethanaminium iodide 
• 88611-67-0 6-acetamido-1,2,3,4-tetrahydronaphthalen-1-one 
• 103602-85-3 6-(acetylamino)-1,2,3,4-tetrahydro-1-oxo-2-naphthalenideneacetic acid 
• 103602-89-7 (+)-6-(acetylamino)-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid 
• 103422-65-7 6-amino-1,2,3,4-tetrahydro-1-oxo-2-naphthaleneacetic acid hydrochloride 
• 103602-78-4 6-(acetylamino)-1,2,3,4-tetrahydro-1-oxonaphthalene-2-acetic acid 
• 104107-19-9 (6-acetamido-1-oxo-1,2,3,4-tetrahydronaphth-2-yl)acetamide 
• 108-24-7 acetic anhydride 
• 103422-66-8 dl-8-amino-4,4a,5,6-tetrahydro-2H-benzo(h)-cinnolin-3-one 
• 103422-63-5 6-acetylamino-2-[(dimethylamino)methyl]-1-tetralone 

Downstream Products

• 121866-04-4 8-[(2-chloropropionyl)amino]-4,4a,5,6-tetrahydrobenzo[h]cinnolin-3(2H)-one 
• 104107-08-6 8-cyano-4,4a,5,6-tetrahydrobenzocinnolin-3<2H>-one 

Relevant articles and documents

Inotropic, vasodilator and low Km, cAMP-selective, cGMP-inhibited phosphodiesterase (PDE III) inhibitory activities of 4a-methyl-4,4a-dihydro-5H-indenopyridazin-3(2H)-ones and 4a-methyl-4,4a,5,6-tetrahydrobenzocinnolin-3(2H)-ones

Novel 7-substituted-4,4a-dihydro-4a-methyl-5H-indenopyridazin-3-ones and 8-substituted-4a-methyl-benzocinnolin-3-ones have been synthesized and their PDE III inhibitory, inotropic and vasodilator potencies compared with those of their normethyl analogues and their bicyclic 4,5-dihydro-6-phenylpyridazinone analogues.The structure-activity relationships of the tricyclic pyridazinones differ from those of bicyclic pyridazinones mainly in respect of the effect of introducing the methyl group into the pyridazinone ring.Whilst in the4,5-dihydro-6-phenylpyridazin-3(2H)-ones, introduction of a 5-methyl group has been widely reported to lead to compounds of significantly greater potency, the novel tricyclic 4a-methylpyridazinones showed similar levels of inotropic, vasodilator and PDE III inhibitory potency to their normethyl analogues.Possible reasons for this difference in behaviour are discussed.

Tricyclic dihydropyridazinones and pharmaceutical compositions containing them

The tricyclic dihydropyridazinone derivatives having formula I STR1 are endowed with interesting hypotensive, vasodilating, antiaggregant, antithrombotic and cytoprotective properties and are therefore useful in human or veterinary medicine.