1036260-43-1

Basic information

• Product Name: (CIS)-3-AMINOCYCLOBUTANOL
• Synonyms: (CIS)-3-AMINOCYCLOBUTANOL;Cyclobutanol, 3-aMino-, cis-;(1s,3s)-3-aMinocyclobutanol
• CAS NO: 1036260-43-1
• Molecular Formula: C4H9NO
• Molecular Weight: 87.12036
• Mol File: 1036260-43-1.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 157.6 °C at 760 mmHg
• Flash Point: 49.1 °C
• Appearance: /
• Density: 1.153g/cm³
• PKA: 15.00±0.40(Predicted)
• CAS DataBase Reference: (CIS)-3-AMINOCYCLOBUTANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (CIS)-3-AMINOCYCLOBUTANOL(1036260-43-1)
• EPA Substance Registry System: (CIS)-3-AMINOCYCLOBUTANOL(1036260-43-1)

Safety Data

• Hazardous Substances Data: 1036260-43-1(Hazardous Substances Data)

Usage

General Description

(CIS)-3-Aminocyclobutanol is an important chemical compound which falls under the category of amines, specifically cycloalkylamines. Its molecular formula is C4H9NO. It is distinguished by its geometric isomerism, having a "cis" configuration where two higher priority groups are present on the same side of the chemical bond. (CIS)-3-AMINOCYCLOBUTANOL is often found in the form of a clear, colorless liquid and may be used in various chemical reactions as an intermediate. Properties such as boiling point, melting point or specific optical rotation of this substance can vary depending upon different factors like purity or temperature. As a chemical, it should be handled with care, following safety guidelines to avoid any hazardous impacts.

Synthetic route

(1S,3S)-3-aminocyclobutan-1-ol (1036260-43-1) + 6-bromo-4-chloroquinoline-3-carboxylic acid ethyl ester (206257-39-8) → ethyl 6-bromo-4-[(cis-3-hydroxycyclobutyl)amino]quinoline-3-carboxylate

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide at 80 - 90℃; Inert atmosphere;	93%

(1S,3S)-3-aminocyclobutan-1-ol (1036260-43-1) + 4-chloro-7-fluoro-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide → 7-fluoro-4-((cis-3-hydroxycyclobutyl)amino)-6-(6-(methoxymethyl)pyridin-3-yl)quinoline-3-carboxamide

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In N,N-dimethyl acetamide Inert atmosphere; Heating;	72%

(1S,3S)-3-aminocyclobutan-1-ol (1036260-43-1) + 2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-2-phenylpropanoic acid → 2-(5-amino-2-(furan-2-yl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-7-yl)-N-((1s,3s)-3-hydroxycyclobutyl)-2-phenylpropanamide

Conditions	Yield
With N-ethyl-N,N-diisopropylamine; HATU In tetrahydrofuran at 20℃;	44%

(1S,3S)-3-aminocyclobutan-1-ol (1036260-43-1) + 7-methoxyquinoline-3-carboxylic acid (474659-26-2) → N-((1s,3s)-3-hydroxycyclobutyl)-7-methoxyquinoline-3-carboxamide

Conditions	Yield
Stage #1: 7-methoxyquinoline-3-carboxylic acid With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; for 0.0833333h; Stage #2: (1S,3S)-3-aminocyclobutan-1-ol In N,N-dimethyl-formamide	21%

(3R,3'R,4'S,6'S,8'R,8a'S)-6-chloro-8'-(3-chloro-2-fluorophenyl)-6'-neopentyl-3',4'-diphenyl 3',4',8',8a'-tetrahydrospiro[indoline-3,7'-pyrrolo[2,1-c][1,4]oxazine]-1',2(6'H)-dione (897365-81-0) + (1S,3S)-3-aminocyclobutan-1-ol (1036260-43-1) → C41H42Cl2FN3O4 (1443749-27-6)

Conditions	Yield
In tetrahydrofuran at 20℃; for 12h; Inert atmosphere;	2.13 g

Downstream Products

• 1443749-27-6 C₄₁H₄₂Cl₂FN₃O₄