1036271-79-0

Basic information

• Product Name: (Z)-3-chloro-3-(3-fluorophenyl)acrylaldehyde
• Synonyms: (Z)-3-chloro-3-(3-fluorophenyl)acrylaldehyde
• CAS NO: 1036271-79-0
• Molecular Weight: 184.597
• Mol File: 1036271-79-0.mol

Chemical Properties

• CAS DataBase Reference: (Z)-3-chloro-3-(3-fluorophenyl)acrylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: (Z)-3-chloro-3-(3-fluorophenyl)acrylaldehyde(1036271-79-0)
• EPA Substance Registry System: (Z)-3-chloro-3-(3-fluorophenyl)acrylaldehyde(1036271-79-0)

Safety Data

• Hazardous Substances Data: 1036271-79-0(Hazardous Substances Data)

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 455-36-7 1-(3-fluorophenyl)ethanone 

Downstream Products

• 1036270-97-9 C₂₀H₁₇FO₄S 

Relevant articles and documents

Efficient synthesis of 4- And 5-substituted 2-aminopyrimidines by coupling of β-Chlorovinyl Aldehydes and Guanidines

A general, practical, and simple synthesis of functionalized 2-aminopyrimidines starting from β-chlorovinyl aldehydes and amidines is reported. In the presence of potassium carbonate, various ketones have been efficiently transformed into the pyrimidine derivatives by a two-step sequence involving the Vilsmeier-Haack reaction followed by a condensation reaction with guanidines. The protocol is distinguished by operational simplicity, inexpensive reagents, and functional-group tolerance. In many cases, pure solid products can be obtained in high to excellent yields without using column chromatography. The synthetic value of the method was demonstrated by the efficient synthesis of steroidal pyrimidines and a precursor of the antitumor agents Imatinib and Mocetinostat.

Base-Promoted Intermolecular Cyclization of Substituted 3-Aryl(Heteroaryl)-3-chloroacrylaldehydes and Tetrahydroisoquinolines: An Approach to Access Pyrrolo[2,1-a]isoquinolines

We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl(heteroaryl)-3-chloroacrylaldehydes and tetrahydroisoquinolines in one pot. The reaction provides a facile and practical synthesis of pyrrolo[2,1-a]isoquinolines. A number of pyrrolo[2,1-a]isoquinolines were synthesized in moderate to high yields (up to 97%).

Design, synthesis, and biological evaluation of thiophene analogues of chalcones

Chalcones are characterized by possessing an enone moiety between two aromatic rings. A series of chalcone-like agents, in which the double bond of the enone system is embedded within a thiophene ring, were synthesized and evaluated for antiproliferative