1036273-20-7

Basic information

• Product Name: 2,4,5-trifluorophenylacetic acid methyl ester
• Synonyms: 2,4,5-trifluorophenylacetic acid methyl ester
• CAS NO: 1036273-20-7
• Molecular Weight: 204.149
• Mol File: 1036273-20-7.mol

Chemical Properties

• CAS DataBase Reference: 2,4,5-trifluorophenylacetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,5-trifluorophenylacetic acid methyl ester(1036273-20-7)
• EPA Substance Registry System: 2,4,5-trifluorophenylacetic acid methyl ester(1036273-20-7)

Safety Data

• Hazardous Substances Data: 1036273-20-7(Hazardous Substances Data)

Upstream product

• 1036273-12-7 methyl 2-(2,4,5-trifluorophenyl)-2-chloroacetate 
• 77-76-9 2,2-dimethoxy-propane 
• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 67-56-1 methanol 
• 327-52-6 1-bromo-2,4,5-trifluorobenzene 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 209995-38-0 (2,4,5-trifluorophenyl)acetic acid 
• 111991-20-9 2-(2,4,5-trifluorophenyl)acetaldehyde 
• 883267-70-7 2-(2,4,5-trifluorophenyl)ethanol 
• 1476070-53-7 C₁₅H₂₀F₃NO₅S 
• 1476070-52-6 taurine 2-(2,4,5-trifluorophenyl)ethyl ester hydrochloride 
• 1476070-60-6 C₂₃H₂₈F₃N₃O₈S₂ 
• 1476070-57-1 C₂₃H₂₈F₃N₃O₉S 
• 1476070-72-0 N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester 
• 1476070-69-5 N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester 
• 1476070-66-2 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-2-thiopyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine2-(2,4,5-trifluorophenyl)ethyl ester 
• 1476070-63-9 2',3'-O-isopropylidene-N-[(1-β-D-ribofuranosyl-1H-pyrimidin-5-yl)methyl]-N-trifluoroacetyltaurine 2-(2,4,5-trifluorophenyl)ethyl ester 
• 1448993-57-4 C₁₈H₂₃F₃O 

Relevant articles and documents

Preparation method of 2, 4, 5-trifluorophenylacetic acid

The invention provides a preparation method of 2, 4, 5-trifluorophenylacetic acid. The method comprises the following steps: 1) reacting 2, 4, 5-trifluorobromobenzene with metal magnesium to obtain 2, 4, 5-trifluorophenyl magnesium bromide; 2) reacting 2, 4, 5-trifluorophenyl magnesium bromide with halogenated acetate to prepare an intermediate A; 3) hydrolyzing the intermediate A in an alkaline solution or an acidic solution to obtain 2, 4, 5-trifluorophenylacetic acid. The structure of the intermediate A is shown as the following structure, wherein R represents a C1-C10 alkyl group. The preparation method of 2, 4, 5-trifluorophenylacetic acid provided by the invention has the advantages of simple process flow, low cost, environmental friendliness and mild conditions.

Synthesis and bio-evaluation of natural butenolides-acrylate conjugates

A series of novel 3-aryl-4-hydroxy-2(5H) furanone-acrylate hybrids were designed and synthesized based on the natural butenolides and acrylates scaffolds. The structures of the prepared compounds were characterized by 1H-NMR, 13C-NMR and electrospray ionization mass spectrometry (ESI-MS), and the bioactivity of the target compounds against twelve phytopathogenic fungi was investigated. The preliminary in vitro antifungal activity screening showed that most of the target compounds had moderate inhibition on various pathogenic fungi at the concentration of 100 mg·L?1, and presented broad-spectrum antifungal activities. Further studies also indicated that compounds 7e and 7k still showed some inhibitory activity against Pestallozzia theae, Sclerotinia sclerotiorum and Gibberella zeae on rape plants at lower concentrations, which could be optimized as a secondary lead for further research.

Stereoselective synthesis of 3,4-di-substituted mercaptolactones via photoredox-catalyzed radical addition of thiophenols

A visible light mediated radical addition of thiophenols on 4-phenylbut-3-enoic acids to give diastereoselective synthesis of 3,4-disubstituted γ-lactones is reported. The reaction precludes the conventional prerequisite of conjugate addition. Furthermore, the lactones were successfully utilized in the synthesis of γ-ketoamides.

Mt-tRNA components: Synthesis of (2-Thio)uridines modified with blocked glycine/taurine moieties at C-5,1

In this paper, we discuss the usefulness of reductive amination of 5-formyl-2′,3′-O-isopropylidene(-2-thio)uridine with glycine or taurine esters in the presence of sodium triacetoxyborohydride (NaBH(OAc) 3) for the synthesis of the native mitochondrial (mt) tRNA components 5-carboxymethylaminomethyl(-2-thio)uridine (cmnm5(s2)U) and 5-taurinomethyl(-2-thio)uridine (τm5(s2)U) with a blocked amino acid function. 2-(Trimethylsilyl)ethyl and 2-(p-nitrophenyl)ethyl esters of glycine and 2-(2,4,5-trifluorophenyl)ethyl ester of taurine were selected as protection of carboxylic and sulfonic acid residues, respectively. The first synthesis of 5-formyl-2′,3′-O-isopropylidene-2-thiouridine is also reported.

PROCESS FOR THE PREPARATION OF FLUOROPHENYLACETIC ACIDS AND DERIVATIVES THEREOF

The object of the present invention is a process for the preparation of fluorophenylacetic acids and derivatives thereof, particularly of 2,4, 5-trifluorophenylacetic acid, starting from the corresponding mandelic acids.