1036387-23-1Relevant articles and documents
ALKYLPHENYL COMPOUNDS
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Page/Page column 42, (2019/02/25)
Disclosed are compounds of Formula (I): (I) or a salt thereof, wherein: X is -CH2- or -C(O)-; R1 is -OH or -OP(O)(OH)2; L is a bond, -CH2-, or -C(O)-; R2 is n-C6-8 alkyl; each R3 is independently selected from Cl and -CH3; and n is zero, 1, or 2; provided that if X is -CH2-, then L is -CH2- or -C(O)-. Also disclosed are methods of using such compounds as selective agonists for G protein coupled receptor SlP1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
SPHINGOSINE-1 -PHOSPHATE RECEPTOR AGONIST AND ANTAGONIST COMPOUNDS
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Page/Page column 79-80, (2008/12/07)
The present invention is directed to novel, potent, and selective agents, which are agonists or antagonists of the one or more of the individual receptors of the S1P receptor family. The compounds of the invention are useful as therapeutics for treating medical conditions associated with agonism or antagonism of the individual receptors of the S1P receptor family.