19398-47-1Relevant articles and documents
Inter-and intramolecular annulation strategies to a cyclopentanone building block containing an all-carbon quaternary stereogenic center
Penrose, Stephen D.,Stott, Andrew J.,Breccia, Perla,Haughan, Alan F.,Bürli, Roland W.,Jarvis, Rebecca E.,Dominguez, Celia
supporting information, p. 1401 - 1404 (2015/03/30)
Synthesis of (S)-2-methyl-3-fluorophenyl cyclopentanone methyl ester (1S)-1 has been achieved by both inter-and intramolecular alkylation reactions on multigram scale, using chiral pool reagents. The intramolecular variant is a novel example of a chiral bis-electrophile reacting with a carbon nucleophile to form an enantiomerically pure all-carbon quaternary center.
HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF
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Paragraph 00144; 00155, (2014/10/15)
Provided are certain histone deacetylase (HDAC) inhibitors of Formula I, compositions thereof, and methods of their use.
