1036397-70-2

Basic information

• Product Name: C₁₇H₁₉F₃IN₃O
• CAS NO: 1036397-70-2
• Molecular Weight: 465.257
• Mol File: 1036397-70-2.mol

Chemical Properties

• CAS DataBase Reference: C₁₇H₁₉F₃IN₃O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₇H₁₉F₃IN₃O(1036397-70-2)
• EPA Substance Registry System: C₁₇H₁₉F₃IN₃O(1036397-70-2)

Safety Data

• Hazardous Substances Data: 1036397-70-2(Hazardous Substances Data)

Upstream product

• 1036397-01-9 [2-(4,5-diiodo-2-methoxymethylimidazol-1-yl)ethyl]carbamic acid tert-butyl ester 
• 1036396-99-2 4,5-diiodo-2-(methoxymethyl)-1H-imidazole 
• 960412-69-5 2-methoxymethyl-1-trityl-1H-imidazole 
• 1036397-05-3 C₇H₁₂IN₃O 
• 166947-09-7 3-(4-trifluoromethylphenyl)propanal 
• 1036397-03-1 [2-(4-iodo-2-methoxymethylimidazol-1-yl)ethyl]carbamic acid tert-butyl ester 

Downstream Products

• 1036397-68-8 1-iodo-3-methoxymethyl-8-[2-(4-trifluoromethylphenyl)ethyl]-5,6-dihydro-8H-imidazo[1,5-a]pyrazine-7-carboxylic acid tert-butyl ester 

Relevant articles and documents

Synthesis, structure-activity relationship studies, and identification of novel 5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine derivatives as dual orexin receptor antagonists. Part 1

A novel series of non-peptidic OX1R/OX2R orexin receptor antagonists was prepared by heterocyclic replacement of the dimethoxyphenyl moiety contained in the tetrahydroisoquinoline core skeleton of almorexant. Introduction of substituted imidazole moieties delivered potent dual orexin receptor antagonists with nanomolar potency for hOX1R and hOX2R suitable for further fine-tuning. The preparation of these novel orexin receptor antagonists and the outcome of preliminary structure-activity relationship studies are described in this communication.