10364-67-7 Usage
General Description
3-(4-Nitrophenyl)-5-propyl-1,2,4-oxadiazole is a chemical compound with the molecular formula C11H11N3O3. It is a heterocyclic organic compound that contains a five-membered ring consisting of three nitrogen atoms and two oxygen atoms. 3-(4-NITROPHENYL)-5-PROPYL-1,2,4-OXADIAZOLE is known for its nitrophenyl and propyl substituents, which contribute to its unique chemical properties. 3-(4-Nitrophenyl)-5-propyl-1,2,4-oxadiazole has potential applications in the field of medicinal chemistry, particularly in the development of pharmaceuticals and biologically active compounds. Its chemical structure makes it an interesting target for further study and potential use in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 10364-67-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,3,6 and 4 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 10364-67:
(7*1)+(6*0)+(5*3)+(4*6)+(3*4)+(2*6)+(1*7)=77
77 % 10 = 7
So 10364-67-7 is a valid CAS Registry Number.
10364-67-7Relevant articles and documents
Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides
Conole, Daniel,Beck, Thorsten M.,Jay-Smith, Morgan,Tingle, Malcolm D.,Eason, Charles T.,Brimble, Margaret A.,Rennison, David
, p. 2220 - 2235 (2014/04/17)
A number of isosteres (oxadiazoles, thiadiazoles, tetrazoles and diazines) of benzocaine were prepared and evaluated for their capacity to induce methemoglobinemia - with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed within each series, with 1,2,4-oxadiazole 3 (metHb% = 61.0 ± 3.6) and 1,3,4-oxadiazole 10 (metHb% = 52.4 ± 0.9) demonstrating the greatest activity. Of the 5 candidates (compounds 3, 10, 11, 13 and 23) evaluated in vivo, failure to induce a lethal end-point at doses of 120 mg/kg was observed in all cases. Inadequate metabolic stability, particularly towards hepatic enzymes such as the CYPs, was postulated as one reason for their failure.
