10364-76-8

Basic information

• Product Name: 4-(5-Propyl-1,2,4-oxadiazol-3-yl)aniline
• Synonyms: 4-(5-Propyl-1,2,4-oxadiazol-3-yl)aniline
• CAS NO: 10364-76-8
• Molecular Formula: C₁₁H₁₃N₃O
• Molecular Weight: 203.24042
• Mol File: 10364-76-8.mol
• Article Data: 1

Chemical Properties

• Melting Point: 88 °C
• Boiling Point: 375.8±44.0 °C(Predicted)
• Appearance: /
• Density: 1.157±0.06 g/cm3(Predicted)
• PKA: 1.99±0.10(Predicted)
• CAS DataBase Reference: 4-(5-Propyl-1,2,4-oxadiazol-3-yl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(5-Propyl-1,2,4-oxadiazol-3-yl)aniline(10364-76-8)
• EPA Substance Registry System: 4-(5-Propyl-1,2,4-oxadiazol-3-yl)aniline(10364-76-8)

Safety Data

• Hazardous Substances Data: 10364-76-8(Hazardous Substances Data)

Upstream product

• 10364-67-7 5-propyl-3-(4-nitrophenyl)-1,2,4-oxadiazole 
• 192332-48-2 (Z)-4-nitrobenzamidoxime 
• 619-72-7 4-nitrobenzonitrile 
• 555-16-8 4-nitrobenzaldehdye 

Relevant articles and documents

Synthesis and methemoglobinemia-inducing properties of benzocaine isosteres designed as humane rodenticides

A number of isosteres (oxadiazoles, thiadiazoles, tetrazoles and diazines) of benzocaine were prepared and evaluated for their capacity to induce methemoglobinemia - with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed within each series, with 1,2,4-oxadiazole 3 (metHb% = 61.0 ± 3.6) and 1,3,4-oxadiazole 10 (metHb% = 52.4 ± 0.9) demonstrating the greatest activity. Of the 5 candidates (compounds 3, 10, 11, 13 and 23) evaluated in vivo, failure to induce a lethal end-point at doses of 120 mg/kg was observed in all cases. Inadequate metabolic stability, particularly towards hepatic enzymes such as the CYPs, was postulated as one reason for their failure.