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1036403-22-1

6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one

    Cas No: 1036403-22-1

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  • 1036403-22-1 Structure

  • Basic information

    1. Product Name: 6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one
    2. Synonyms: 6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one
    3. CAS NO:1036403-22-1
    4. Molecular Formula:
    5. Molecular Weight: 454.298
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1036403-22-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one(CAS DataBase Reference)
    10. NIST Chemistry Reference: 6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one(1036403-22-1)
    11. EPA Substance Registry System: 6-(benzyloxymethyl)-8-(3-bromo-4-fluorobenzyl)pyrido[3,2-d]pyridazin-5(6H)-one(1036403-22-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1036403-22-1(Hazardous Substances Data)

1036403-22-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1036403-22-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,6,4,0 and 3 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1036403-22:
(9*1)+(8*0)+(7*3)+(6*6)+(5*4)+(4*0)+(3*3)+(2*2)+(1*2)=101
101 % 10 = 1
So 1036403-22-1 is a valid CAS Registry Number.

1036403-22-1Relevant articles and documents

Discovery and SAR of orally efficacious tetrahydropyridopyridazinone PARP inhibitors for the treatment of cancer

Zhu, Gui-Dong,Gong, Jianchun,Gandhi, Viraj B.,Liu, Xuesong,Shi, Yan,Johnson, Eric F.,Donawho, Cherrie K.,Ellis, Paul A,Bouska, Jennifer J.,Osterling, Donald J.,Olson, Amanda M.,Park, Chang,Luo, Yan,Shoemaker, Alexander,Giranda, Vincent L.,Penning, Thomas D.

, p. 4635 - 4645 (2012)

PARP-1, the most abundant member of the PARP superfamily of nuclear enzymes, has emerged as a promising molecular target in the past decade particularly for the treatment of cancer. A number of PARP-1 inhibitors, including veliparab discovered at Abbott, have advanced into different stages of clinical trials. Herein we describe the development of a new tetrahydropyridopyridazinone series of PARP-1 inhibitors. Many compounds in this class, such as 20w, displayed excellent potency against the PARP-1 enzyme with a Ki value of 50 value of 1 nM in a C41 whole cell assay. The presence of the NH in the tetrahydropyridyl ring of the tetrahydropyridopyridazinone scaffold improved the pharmacokinetic properties over similar carbon based analogs. Compounds 8c and 20u are orally available, and have demonstrated significant efficacy in a B16 murine xenograft model, potentiating the efficacy of temozolomide (TMZ).

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