1036404-01-9

Upstream product

• 72597-18-3 (2R)-(+)-phenylmethyl 2-(hydroxymethyl)pyrrolidine-1-carboxylate 
• 50463-82-6 (2R)-(+)-phenylmethyl 2-formylpyrrolidine-1-carboxylate 
• 197230-34-5 (R)-2-allyl-(N-benzyloxycarbonyl) pyrrolidine 
• 1597449-88-1 (2R,Rs)-2-allyl-(N-tert-butylsulfinyl)pyrrolidine 
• 1597449-87-0 (4R,R_S)-N-(tert-butylsulfinyl)-7-bromohept-1-en-4-amine 
• 1000806-50-7 (E)-(6-benzyloxycarbonylamino)-2-hexenal 

Downstream Products

• 61350-64-9 (R)-2-{1-[(benzyloxy)carbonyl]pyrrolidin-2-yl}acetic acid 
• 1597449-89-2 (2R,2′R,S_S)-(N-benzyloxycarbonyl)-2-[2′-(tert-butylsulfinamine)-4′-pentenyl]pyrrolidine 
• 1597449-90-5 (2R,2′S,R_S)-(N-benzyloxycarbonyl)-2-[(2′-tert-butylsulfinamine)-4′-pentenyl]pyrrolidine 

Relevant academic research and scientific papers

FUMAGILLOL HETEROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING SAME

Disclosed herein, in part, are fumagillol compounds and methods of use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making fumagillol compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

Natural tetraponerines: A general synthesis and antiproliferative activity

A stereocontrolled general methodology to access all natural tetraponerines from (+)-T1 to (+)-T8 is detailed. Two consecutive indium-mediated aminoallylations with the appropriate enantiomer of chiral N-tert- butylsulfinamide and a thermodynamic control at the aminal stereocenter allow the formation of each natural tetraponerine with excellent stereoselectivity. The use of 4-bromobutanal in the first aminoallylation leads to the formation of 5-6-5 tetraponerines, while 5-bromopentanal is required to build the scaffold of 6-6-5 tetraponerines. A cross-metathesis reaction of the second aminoallylation product with cis-3-hexene is used to elongate the side chain up to 5 carbons so as to prepare the tetraponerines T5 to T8. The anticancer activity of these heavier tetraponerines against four different carcinoma human cell lines is examined, observing a promising cytotoxic activity of (+)-T7 against breast carcinoma cell line MCF-7.

Improved protocol for asymmetric, intramolecular heteroatom Michael addition using organocatalysis: Enantioselective syntheses of homoproline, pelletierine, and homopipecolic acid

(Chemical Equation Presented) An improved protocol for the construction of enantioenriched pyrrolidine, indoline, and piperidine rings using an organocatalyzed, intramolecular heteroatom Michael addition is described. Application to the enantioselective synthesis of homoproline, homopipecolic acid, and pelletierine has been accomplished.