1036488-30-8

Basic information

• Product Name: (R)-1-BOC-3-(4-AMINOPHENOXY)-PYRROLIDINE
• Synonyms: (R)-1-BOC-3-(4-AMINOPHENOXY)-PYRROLIDINE;(R)-tert-Butyl 3-(4-aminophenoxy)pyrrolidine-1-carboxylate
• CAS NO: 1036488-30-8
• Molecular Formula: C15H22N2O3
• Molecular Weight: 278.34678
• Mol File: 1036488-30-8.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-1-BOC-3-(4-AMINOPHENOXY)-PYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-BOC-3-(4-AMINOPHENOXY)-PYRROLIDINE(1036488-30-8)
• EPA Substance Registry System: (R)-1-BOC-3-(4-AMINOPHENOXY)-PYRROLIDINE(1036488-30-8)

Safety Data

• Hazardous Substances Data: 1036488-30-8(Hazardous Substances Data)

Usage

General Description

(R)-1-BOC-3-(4-AMINOPHENOXY)-PYRROLIDINE is a chemical compound with a structure that includes a pyrrolidine ring, a BOC-protected amine group, and a 4-aminophenoxy moiety. The BOC group is a common protecting group for amines, which can be removed under acidic conditions. The 4-aminophenoxy group is a substituted phenol with an amino group attached to the para position. These structural features make (R)-1-BOC-3-(4-AMINOPHENOXY)-PYRROLIDINE a versatile molecule for use in organic synthesis, particularly in the preparation of pharmaceuticals and other fine chemicals. It can also be used as a building block in the synthesis of various heterocyclic compounds.

Upstream product

• 1233860-29-1 (S)-tert-butyl 3-(4-nitrophenoxy)pyrrolidine-1-carboxylate 
• 101469-92-5 (S)-3-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 1085838-95-4 (S)-3-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenoxy}-pyrrolidine-1-carboxylic acid tert butyl ester 
• 1229419-15-1 4-((S)-3-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenoxy}-pyrrolidin-1-yl)-benzoic acid 
• 1229419-53-7 4-((S)-3-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenoxy}-pyrrolidin-1-yl)-benzoic acid tert-butyl ester 

Relevant articles and documents

NAMPT inhibitors

Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed.

NEW COMPOUNDS

The present invention encompassescompounds of general formula (1) wherein R1 to R4 , X and n are defined as in claim 1, which are suitable for the treatment of ailments characterised byexcessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

DIAMINOTHIAZOLES

The present invention is directed to novel diaminothiazoles of formula These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdk1. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment 6r control of breast, lung and colon and prostate tumors.