350-46-9

Basic information

• Product Name: 4-Fluoronitrobenzene
• Synonyms: 4-Fluornitrobenzol;4-fluoro-1-nitrobenzene;Benzene,1-fluoro-4-nitro-;Fluoronitrobenzene3;Fluoronitrobenzenecolorlesssolid;4-Fluoronitrobenzene p-Fluoronitrobenzene;1-Fluoro-4-Nitrobenzene(4-Fluoronitrobenzene;p-Fluoronitrobenzene,99%
• CAS NO: 350-46-9
• Molecular Formula: C₆H₄FNO₂
• Molecular Weight: 141.1
• EINECS: 206-502-8
• Product Categories: Aromatic Halides (substituted);Halides;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
• Mol File: 350-46-9.mol
• Article Data: 162

Chemical Properties

• Melting Point: 21 °C(lit.)
• Boiling Point: 205 °C(lit.)
• Flash Point: 182 °F
• Appearance: deep greenish-yellow/Liquid After Melting
• Density: 1.33 g/mL at 25 °C(lit.)
• Vapor Density: >1 (vs air)
• Vapor Pressure: 5.5 mm Hg ( 70 °C)
• Refractive Index: n20/D 1.531(lit.)
• Storage Temp.: Store below +30°C.
• Water Solubility: Insoluble in water.
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• BRN: 606923
• CAS DataBase Reference: 4-Fluoronitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoronitrobenzene(350-46-9)
• EPA Substance Registry System: 4-Fluoronitrobenzene(350-46-9)

Safety Data

• Hazard Codes: Xn,T,Xi
• Statements: 20/21/22-33
• Safety Statements: 36-36/37
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 1
• RTECS: DA1400000
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 350-46-9(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 350-46-9 differently. You can refer to the following data:
1. 4-Nitrofluorobenzene, is an aryl fluorinated building block, and a common intermediate used for the synthesis of many industrial useful compounds. It is used for the preparation of novel soluble aromatic polyimides, such as 1,3,5-Tris(4-aminophenoxy)benzene (TAB).
2. 1-Fluoro-4-nitrobenzene used as a component of hair dyes, as pharmaceutical intermediates. It is also used for the preparation of novel soluble aromatic polyimides

Chemical Properties

yellow liquid

Synthesis Reference(s)

Journal of the American Chemical Society, 78, p. 6034, 1956 DOI: 10.1021/ja01604a022Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8Tetrahedron Letters, 30, p. 7199, 1989 DOI: 10.1016/S0040-4039(01)93933-4

Flammability and Explosibility

Nonflammable

Purification Methods

Crystallise it from EtOH. [Beilstein 5 H 241, 5 IV 719.]

InChI:InChI=1/C6H4FNO2/c7-5-1-3-6(4-2-5)8(9)10/h1-4H

Upstream product

• 462-06-6 fluorobenzene 
• 591-09-3 nitro acetate 
• 456-27-9 4-nitrobenzenediazonium tetrafluoroborate 
• 100-00-5 4-chlorobenzonitrile 
• 121-73-3 3-Nitrochlorobenzene 
• 34467-53-3 p-fluoronitrobenzene anion 
• 54480-44-3 N,N-dimethyl-N'-(4-methoxyphenyl)-1,4-phenylendiamine 
• 455-17-4 (p-fluorophenyl)trimethylsilane 
• 100-01-6 4-nitro-aniline 
• 98-95-3 nitrobenzene 
• 7446-70-0 aluminium trichloride 
• 10544-72-6 dinitrogen tetraoxide 
• 7697-37-2 nitric acid 
• 352-34-1 4-fluoro-1-iodobenzene 

Downstream Products

• 351-83-7 4'-fluoroacetanilide 
• 16124-69-9 4-[(4-nitrophenyl)amino]benzoic acid 
• 85951-93-5 (3,5-dimethyl-phenyl)-(4-nitro-phenyl)-amine 
• 836-30-6 4-ntrophenyl(phenyl)amine 
• 78019-77-9 4-methyl-1-(4-nitrophenyl)piperidine 
• 85002-85-3 3-[2-(4-Nitro-phenoxy)-ethyl]-pyridine 
• 85002-86-4 3-[3-(4-Nitro-phenoxy)-propyl]-pyridine 
• 85002-84-2 4-[2-(6-methyl-pyridin-2-yl)ethoxy]nitrobenzene 
• 85002-89-7 4-Methyl-5-[2-(4-nitro-phenoxy)-ethyl]-thiazole 
• 16365-27-8 2-(4-nitrophenoxy)ethanol 
• 14467-69-7 1,2-bis(4-nitrophenoxy)ethane 
• 79421-42-4 8-(4-nitrophenyl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 29275-99-8 4-nitro-N,N-bis(propan-2-yl)aniline 
• 5464-09-5 N,N-diethyl-N'-(4-nitrophenyl)-1,2-diaminoethane 

Relevant articles and documents

Method for synthesizing nitro (hetero) aromatic hydrocarbon

The invention discloses a method for synthesizing nitro (hetero) aromatic hydrocarbon, and belongs to the field of organic synthesis. According to the method, simple (hetero) aromatic hydrocarbon is taken as an initial raw material and is stirred and reacted in an organic solvent at 40-100 DEG C under the action of a nitration reagent, a lewis acid catalyst and protective gas, and nitro (hetero) aromatic hydrocarbon can be obtained. The method provided by the invention has the advantages of cheap and easily available raw materials, mild reaction conditions, simple preparation process, good chemical selectivity, wide substrate application range, easy amplification and the like, has great application potential, and lays a good foundation for industrial production.

The polyhedral nature of selenium-catalysed reactions: Se(iv) species instead of Se(vi) species make the difference in the on water selenium-mediated oxidation of arylamines

Selenium-catalysed oxidations are highly sought after in organic synthesis and biology. Herein, we report our studies on the on water selenium mediated oxidation of anilines. In the presence of diphenyl diselenide or benzeneseleninic acid, anilines react with hydrogen peroxide, providing direct and selective access to nitroarenes. On the other hand, the use of selenium dioxide or sodium selenite leads to azoxyarenes. Careful mechanistic analysis and 77Se NMR studies revealed that only Se(iv) species, such as benzeneperoxyseleninic acid, are the active oxidants involved in the catalytic cycle operating in water and leading to nitroarenes. While other selenium-catalysed oxidations occurring in organic solvents have been recently demonstrated to proceed through Se(vi) key intermediates, the on water oxidation of anilines to nitroarenes does not. These findings shed new light on the multifaceted nature of organoselenium-catalysed transformations and open new directions to exploit selenium-based catalysis.

Method for efficiently synthesizing fluorine-containing compound

The invention discloses a method for efficiently synthesizing a fluorine-containing compound, and relates to the field of fluorine-containing compound synthesis. The method is a method for generating a corresponding fluorine atom substituted fluorine-containing compound by reacting aromatic chloride or activated chloride serving as a raw material with potassium fluoride under the action of a novel catalyst. The method disclosed by the invention has the advantages of good product selectivity, high efficiency, mild reaction conditions, simplicity and convenience in operation, convenience in application and the like.