103654-51-9Relevant articles and documents
Hormothamnione, a novel cytotoxic styrylchromone from the marine cyanophyte Hormothamnion enteromorphoides Grunow
Gerwick,Lopez,Van Duyne,et al.
, p. 1979 - 1982 (1986)
The first naturally occurring styrylchromone, hormothamnione, was isolated from the marine cyanophyte Hormothamnion enteromorphoides and its structure determined by an x-ray experiment on its triacetate derivative. Hormothamnione is an exceptionally potent cytotoxin to cancer cells in vitro and appears to be a selective inhibitor of RNA synthesis.
SYNTHESIS OF HORMOTHAMNIONE
Alonso, Ricardo,Brossi, Arnold
, p. 735 - 738 (2007/10/02)
Hormothamnione 1 has been obtained from 2,3-dimethyl-5,6,7,8-tetramethoxy-chromone 18 in 63percent yield.Synthesis of the required chromone 18 as well as of the 2 and 3-styryl analogs 5 and 9 are described.