103656-40-2

Basic information

• Product Name: 24-homo-1,25-dihydroxyvitamin D3
• Synonyms: 24-homo-1,25-dihydroxyvitamin D3;24-HoMo Calcitriol;(1R,3S,5Z)-4-Methylene-5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R)-6-hydroxy-1,6-diMethylheptyl]-7a-Methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol;MC 1127;IMpurity D of Calcitriol;Calcitriol Impurities D;(1R,3S,5E)-5-[(2E)-2-[(1R,3As,7Ar)-1-(6-Hydroxy-1,6-Dimethyl-Heptyl)-7A-Methyl-2,3,3A,5,6,7-Hexahydro-1H-Inden-4-Ylidene]Ethylidene]-4-Methylene-Cyclohexane-1,3-Diol;(1R,3S,5E)-5-[(2E)-2-[(1R,3As,7Ar)-1-(6-Hydroxy-1,6-Dimethylheptyl)-7A-Methyl-2,3,3A,5,6,7-Hexahydro-1H-Inden-4-Ylidene]Ethylidene]-4-Methylenecyclohexane-1,3-Diol
• CAS NO: 103656-40-2
• Molecular Formula: C₂₈H₄₆O₃
• Molecular Weight: 430.66304
• Product Categories: Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 103656-40-2.mol

Chemical Properties

• Boiling Point: 575.6°Cat760mmHg
• Flash Point: 240.5°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 1.2E-15mmHg at 25°C
• Refractive Index: 1.544
• PKA: 14.43±0.40(Predicted)
• CAS DataBase Reference: 24-homo-1,25-dihydroxyvitamin D3(CAS DataBase Reference)
• NIST Chemistry Reference: 24-homo-1,25-dihydroxyvitamin D3(103656-40-2)
• EPA Substance Registry System: 24-homo-1,25-dihydroxyvitamin D3(103656-40-2)

Safety Data

• Hazardous Substances Data: 103656-40-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
24-homo-1,25-dihydroxyvitamin D3 is used as a pharmaceutical agent for its potent effects on cell growth regulation and immune responses. It plays a crucial role in managing various health conditions by modulating cellular processes and enhancing the body's immune system.
Used in Research Applications:
In the field of scientific research, 24-homo-1,25-dihydroxyvitamin D3 is utilized as a research tool to study the mechanisms of cell growth and immune system modulation. Its unique properties allow researchers to gain insights into the complex interactions between vitamin D3 and cellular processes, leading to potential breakthroughs in understanding and treating various diseases.
Used in Nutraceutical Formulations:
24-homo-1,25-dihydroxyvitamin D3 is also used as an ingredient in nutraceutical formulations to support bone health and immune function. Its potent effects on cell growth regulation and immune responses make it a valuable addition to supplements and health products aimed at promoting overall well-being and maintaining a healthy lifestyle.

InChI:InChI=1/C28H46O3/c1-19(9-6-7-15-27(3,4)31)24-13-14-25-21(10-8-16-28(24,25)5)11-12-22-17-23(29)18-26(30)20(22)2/h11-12,19,23-26,29-31H,2,6-10,13-18H2,1,3-5H3/b21-11+,22-12+/t19?,23-,24-,25+,26+,28-/m1/s1

Upstream product

• 103656-34-4 (22E)-24-homocholesta-5,22-diene-1α,3β,25-triol 
• 99741-49-8 1α,3β-bis(methoxymethoxy)chola-5,23-dien-22-ol 
• 103656-38-8 1α,3β-diacetoxy-24-homocholest-5-en-25-ol 
• 110655-81-7 (22E)-1α,3β-bis(methoxymethoxy)-27-norcholesta-5,22-dien-26-oic acid ethyl ester 
• 97453-09-3 1α,3β-bismethoxymethoxypregn-5-ene-20S-carbaldehyde 
• 103656-39-9 1α,3β-diacetoxy-24-homocholesta-5,7-dien-25-ol 
• 103656-35-5 (22E)-1α,3β-diacetoxy-24-homocholesta-5,22-dien-25-ol 
• 110655-82-8 (22E)-1α,3β-bis(methoxymethoxy)-24-homocholesta-5,22-dien-25-ol 

Relevant articles and documents

Parallel synthesis of a vitamin D3 library in the solid-phase

A highly efficient synthesis of the vitamin D3 system on solid support is described. Two synthetic strategies for the solid-phase synthesis of vitamin D3 were developed. One is for 11-hydroxy analogues, and the other is for most other synthetic analogues. In the latter strategy, the sulfonate-linked CD-ring 58 was initially immobilized on PS-DES resin to give solid-supported CD-ring 63 (Scheme 10). Similarly, solid-supported CD-ring 63 was prepared by attachment of the CD-ring 10 to the chlorosulfonate resin 64. The vitamin D3 system was synthesized by Horner-Wadsworth-Emmons reaction of the A-ring phosphine oxide to a solid-supported CD-ring, followed by simultaneous introduction of the side chain and cleavage from resin with a Cu1-catalyzed Grignard reagent. Parallel synthesis of the vitamin D3 analogues was accomplished by a split and pool methodology utilizing radio frequency encoded combinatorial chemistry, and a manual parallel synthesizer for side chain diversification and deprotection. Additionally, we demonstrated the synthesis of various A-rings in a similar protocol for efficient preparation of building blocks.