103658-75-9

Upstream product

• 33348-34-4 4-amino-3-iodobenzonitrile 

Downstream Products

• 152918-49-5 O-tert-butyl-4-amino-3-iodobenzylcarbamate 
• 1470058-10-6 C₁₆H₂₂N₂O₃ 
• 1470058-07-1 5-(O-tert-butoxycarbonyl)aminomethyl-2-(2-N,N'-bis-tert-butoxycarbonylguanidinoethyl)-1-N-(4-methylphenylsulfonyl)indole 
• 1470058-06-0 5-(O-tert-butoxycarbonyl)aminomethyl-2-(2-hydroxyethyl)-1-N-(4-methylphenylsulfonyl)indole 
• 1470058-09-3 O-tert-butyl-4-amino-3-(4-N,N'-bis-tert-butoxycarbonylguanidinobut-1-yne-1-yl)benzylcarbamate 
• 1470058-05-9 O-tert-butyl-3-iodo-4-(4-methylphenylsulfonylamido)benzylcarbamate 

Relevant academic research and scientific papers

LIGANDS FOR ENHANCED IMAGING AND DRUG DELIVERY TO NEUROBLASTOMA CELLS

The present invention concerns aminobenzylguanidine derivative ligands specifically targeting neuroblastoma cells with an improved cellular uptake. The improved cellular uptake provides for the therapeutic and diagnostic use of the ligands in neuroblastoma-related diseases.

In silico design, synthesis, and screening of novel deoxyhypusine synthase inhibitors targeting HIV-1 replication

The human enzyme deoxyhypusine synthase (DHS) is an important host cell factor that participates in the post-translational hypusine modification of eukaryotic initiation factor 5A (eIF-5A). Hypusine-modified eIF-5A plays a role in a number of diseases, in

Synthesis and structural optimization of multiple H-bonding region of diarylalkyl (thio)amides as novel TRPV1 antagonists

Structural optimization of multiple H-bonding region and structure-activity relationship of diarylalkyl amides/thioamides as novel TRPV1 antagonists are described. In particular, we identified amide 34o and thioamides 35o and 35r, of which antagonistic activities were highly enhanced by an incorporation of cyano or vinyl-substituent to the multiple H-bonding region. They exhibited potent 45Ca2+ uptake inhibitions in rat DRG neuron with IC50s of 25, 32 and 28 nM, respectively.