103668-99-1

Basic information

• Product Name: 3-(2-Thienyl)benzaldehyde
• Synonyms: 3-(2-THIENYL)BENZALDEHYDE;AKOS BAR-0193;3-THIOPHEN-2-YL-BENZALDEHYDE;3-THIEN-2-YLBENZALDEHYDE;3-(5-Bromothiophen-2-yl)benzaldehyde;3-(5-Chlorothiophen-2-yl)benzaldehyde;3-(5-Iodothiophen-2-yl)benzaldehyde
• CAS NO: 103668-99-1
• Molecular Formula: C₁₁H₈OS
• Molecular Weight: 188.25
• Product Categories: API intermediates
• Mol File: 103668-99-1.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 330 °C at 760 mmHg
• Flash Point: 123.8 °C
• Appearance: Light yellow powder
• Density: 1.207 g/cm³
• Vapor Pressure: 0.000172mmHg at 25°C
• Refractive Index: 1.637
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-(2-Thienyl)benzaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Thienyl)benzaldehyde(103668-99-1)
• EPA Substance Registry System: 3-(2-Thienyl)benzaldehyde(103668-99-1)

Safety Data

• Hazard Codes: Xn
• Statements: 20/22-36/37/38
• Safety Statements: 22-26-36/37/39
• Hazardous Substances Data: 103668-99-1(Hazardous Substances Data)

Usage

General Description

3-(2-Thienyl)benzaldehyde, also known as thiophene-2-carboxaldehyde, is a chemical compound with a molecular formula C11H8OS. It is a yellow liquid with a strong and pungent odor. 3-(2-Thienyl)benzaldehyde is commonly used as a flavoring agent in the food industry and as a fragrance ingredient in the perfume industry. It is also used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. Additionally, 3-(2-Thienyl)benzaldehyde has been studied for its potential biological and pharmacological properties, and may have applications in medicinal and healthcare products.

InChI:InChI=1/C11H8OS/c12-8-9-3-1-4-10(7-9)11-5-2-6-13-11/h1-8H

Upstream product

• 6165-68-0 thiophene boronic acid 
• 75148-49-1 3-bromobenzaldehyde diethylacetal 
• 3132-99-8 m-bromobenzoic aldehyde 
• 188290-36-0 thiophene 
• 15106-95-3 bis(thien-2-yl)zinc 
• 103668-90-2 2-oxatricyclo<2.2.2.0^3,5>octan-6-one 
• 87199-16-4 3-Formylphenylboronic acid 
• 3437-95-4 2-Iodothiophene 
• 103668-95-7 6-(2-thienyl)-2-oxatricyclo<2.2.2.0^3,5>octan-6-ol 

Downstream Products

• 1236136-58-5 N-(2-nitrophenyl)-4-((3-(thiophen-2-yl)benzylamino)methyl)benzamide 
• 1160456-97-2 C₁₈H₁₈O₃S 

Relevant articles and documents

Generation of aryl radicals from arylboronic acids by manganese(III) acetate: Synthesis of biaryls and heterobiaryls

The efficient generation of aryl radicals from arylboronic acids by manganese(III) acetate is described. In aromatic solvents, in situ generated aryl radicals afford the corresponding biaryls in very good yields. This method works selectively, and yields

New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Postintoxication Model

The synthesis and inhibitory potencies against botulinum neurotoxin serotype A light chain (BoNT/A LC) using in vitro HPLC based enzymatic assay for various steroidal, benzothiophene, thiophene, and adamantane 4-aminoquinoline derivatives are described. In addition, the compounds were evaluated for the activity against BoNT/A holotoxin in mouse embryonic stem cell derived motor neurons. Steroidal derivative 16 showed remarkable protection (up to 89% of uncleaved SNAP-25) even when administered 30 min postintoxication. This appears to be the first example of LC inhibitors antagonizing BoNT intoxication in mouse embryonic stem cell derived motor neurons (mES-MNs) in a postexposure model. Oral administration of 16 was well tolerated in the mouse up to 600 mg/kg, q.d. Although adequate unbound drug levels were not achieved at this dose, the favorable in vitro ADMET results strongly support further work in this series.

Propionic Acid Derivatives and Methods of Use Thereof

Provided herein are compounds and pharmaceutical compositions of formula I where R1, R2, R3, R4, R5 and R6 are as described herein. Also provided pharmaceutically acceptable salts or stereoisomers of these compounds. In addition methods are provided for inhibiting the binding of an integrin to treat various pathophysiological conditions.