103675-29-2

Basic information

• Product Name: 2(5H)-Furanone, 4-(3-methylphenyl)-
• CAS NO: 103675-29-2
• Molecular Formula: C11H10O2
• Molecular Weight: 174.199
• Mol File: 103675-29-2.mol

Chemical Properties

• CAS DataBase Reference: 2(5H)-Furanone, 4-(3-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(5H)-Furanone, 4-(3-methylphenyl)-(103675-29-2)
• EPA Substance Registry System: 2(5H)-Furanone, 4-(3-methylphenyl)-(103675-29-2)

Safety Data

• Hazardous Substances Data: 103675-29-2(Hazardous Substances Data)

Upstream product

• 86650-49-9 3-(3-tolyl)-3-butenoic acid 
• 17933-03-8 m-tolylboronic acid 
• 189078-68-0 tert-butyl buta-2,3-dienoate 
• 541-57-1 4-hydroxy-2(5H)-furanone 
• 625-95-6 3-Iodotoluene 
• 103675-23-6 (Z)-4-(Tetrahydro-pyran-2-yloxy)-3-m-tolyl-but-2-enoic acid methyl ester 
• 201230-82-2 carbon monoxide 
• 766-82-5 1-ethynyl-3-methyl-benzene 

Downstream Products

• 80866-23-5 3-(3-methylphenyl)furan 

Relevant articles and documents

Oxidative Cyclization of β,γ-Unsaturated Carboxylic Acids Using Hypervalent Iodine Reagents: An Efficient Synthesis of 4-Substituted Furan-2-ones

The oxidative cyclization of β-substituted β,γ-unsaturated carboxylic acids using a hypervalent iodine reagent to provide 4-substituted furan-2-one products, is reported. In this cyclization, the use of a highly electrophilic PhI(OTf) 2, which is in situ prepared from PhI(OAc) 2 and Me 3 SiOTf, is crucial. Depending on the substitution pattern at the α-position of the substrates, furan-2(5 H)-ones or furan-2(3 H)-ones are produced. Thus, the present method offers a useful tool for accessing various types of 4-substituted furan-2-ones that are important structural motifs in the field of organic chemistry and medicinal chemistry.

Gold-catalyzed cascade oxidative cyclization and arylation of allenoates

An AuI/AuIII catalytic system was found to be effective for the cascade oxidative arylation and cyclization of allenoates with arylboronic acids to give the corresponding cyclic adducts in moderate yields. This reaction system constitutes a new method for the synthesis of β-aryl-γ-butenolides under mild conditions. Based on the previous mechanistic studies, a proposed AuI/AuIII redox catalytic cycle has been outlined. An AuI/AuIII catalytic system was found to be effective for the cascade oxidative arylation and cyclization of allenoates with various arylboronic acids to give the corresponding cyclic adducts in moderate yields. This reaction system enabled the synthesis β-aryl-γ-butenolides under mild conditions. Based on previous mechanistic studies, an AuI/AuIII redox catalytic cycle has been outlined. Copyright

Rapid access to 4-substituted-pyrones and 2(5H)-furanones via a palladium-catalyzed C-OH bond activation

An efficient palladium-catalyzed cross-coupling reaction of 4-hydroxy-pyrone or 4-hydroxy-2(5H)-furanone with arylboronic acid is described, which affords the 4-substituted-pyrones and 2(5H)-furanones in good yields. This transformation proceeds through a C-OH bond activation under mild conditions.

An expedient palladium-mediated route to 3-arylfurans

A facile route to 3-arylfurans has been developed by employing the Heck reaction between 2,5-dihydro-2,5-dimethoxyfuran and aryl iodides as the key step.

Reductive Carbonylation of Acetylenes under Water-Gas Shift Reaction Conditions. Synthesis of Furan-2(5H)-ones from Terminal and Non-substituted Acetylenes

Under water-gas reaction conditions terminal and non-substituted acetylenes are selectively converted into furan-2(5H)-ones by catalysis with a rhodium carbonyl cluster.