541-57-1

Basic information

• Product Name: 4-Hydroxy-2(5H)-furanone
• Synonyms: BETA-TETRONIC ACID;4-HYDROXYFURAN-2(5H)-ONE;4-HYDROXY-2(5H)-FURANONE;4-HYDROXY-2,5-DIHYDROFURAN-2-ONE;Tetronicacid,beta-;4-Hydroxy-2,5-dihydrofuran-2-one98%;B-Tetronic acid;4-HYDROXY-2(5H)-FURANONE 98%
• CAS NO: 541-57-1
• Molecular Formula: C₄H₄O₃
• Molecular Weight: 100.07
• EINECS: 208-785-3
• Product Categories: Ring Systems
• Mol File: 541-57-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 135-137 °C
• Boiling Point: 316.03°C
• Flash Point: 161.959 °C
• Appearance: Light yellow-beige/Crystalline Powder
• Density: 1.5510
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.4688 (estimate)
• Storage Temp.: 2-8°C
• PKA: 3.55±0.10(Predicted)
• Water Solubility: soluble
• BRN: 108442
• CAS DataBase Reference: 4-Hydroxy-2(5H)-furanone(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Hydroxy-2(5H)-furanone(541-57-1)
• EPA Substance Registry System: 4-Hydroxy-2(5H)-furanone(541-57-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25
• HazardClass: IRRITANT
• Hazardous Substances Data: 541-57-1(Hazardous Substances Data)

Usage

Chemical Properties

light yellow-beige crystalline powder

Uses

β-Tetronic Acid is a useful reagent in preparation of hydroxylated piperidine alkaloids.

InChI:InChI=1/C4H4O3/c5-3-1-4(6)7-2-3/h1,5H,2H2

Upstream product

• 623-86-9 acetoxy-acetic acid ethyl ester 
• 15667-21-7 D-erythronolactone 
• 128766-63-2 6-hydroxymethyl-2,2-dimethyl-4H-1,3-dioxin-4-one 
• 35594-15-1 ethyl 4-acetoxyacetoacetate 
• 21151-51-9 3-bromo-4-hydroxyfuran-2(5H)-one 
• 69556-70-3 4-methoxy-5H-furan-2-one 

Downstream Products

• 109480-19-5 4-Hydroxy-3-phenylacetyl-5H-furan-2-one 
• 38470-54-1 4-benzylamino-2(5H)-furanone 
• 69556-75-8 4-(benzyloxy)-2(5H)-furanone 
• 30290-18-7 4-(methylamino)furan-2(5H)-one 
• 21151-51-9 3-bromo-4-hydroxyfuran-2(5H)-one 
• 867068-35-7 7-chloro-9-(2-chloro-phenyl)-4,9-dihydro-3H-furo[3,4-b]quinolin-1-one 

Relevant articles and documents

A method for synthesizing tetranoic acid

The invention discloses a synthetic method of tetronic acid. The synthetic method comprises the following steps: firstly oxidizing low-price easily-available natural sodium D-isoascorbate as a raw material through hydrogen peroxide, and acidifying through hydrochloric acid to prepare a key synthetic intermediate, namely erythronolactone; secondly, reacting erythronolactone with sulfonyl chloride to generate crude tetronic acid; finally, simply re-crystallizing obtained crude tetronic acid to obtain pure tetronic acid. The synthetic method has the characteristics of few synthetic steps, simple and convenient process, low synthetic cost, convenience for large-scale industrialized production and the like; finally obtained pure tetronic acid is high in yield and purity, the yield can reach more than 87%, and the purity can reach more than 99%.

Process for the Preparation of Tetronic Acid

Tetronic acid of following Formula (2): is industrially efficiently prepared through a reaction of 4-hydroxy- or 4-alkoxy-acetoacetic acid or an ester thereof of following Formula (1): wherein R1 and R2 each independently represent a hydrogen atom or an alkyl group, by carrying out the reaction in the presence of an organic solvent and an acid but substantially in the absence of water. Product tetronic acid is useful as an intermediate for fine chemicals such as pharmaceuticals, agricultural chemicals, and semiconductor resist polymers.