10368-35-1

Basic information

• Product Name: 2-(4-ethoxyphenyl)acetyl chloride
• Synonyms: 2-(4-ethoxyphenyl)acetyl chloride
• CAS NO: 10368-35-1
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.65
• Mol File: 10368-35-1.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-ethoxyphenyl)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-ethoxyphenyl)acetyl chloride(10368-35-1)
• EPA Substance Registry System: 2-(4-ethoxyphenyl)acetyl chloride(10368-35-1)

Safety Data

• Hazardous Substances Data: 10368-35-1(Hazardous Substances Data)

Usage

Type of compound

Acetyl chloride derivative

Substituent group

4-ethoxyphenyl

Physical state

Colorless to pale yellow liquid

Odor

Pungent

Usage

Reagent in organic synthesis (preparation of pharmaceuticals and agrochemicals), building block in compound production, intermediate in chemical manufacturing processes

Hazards

Flammable, corrosive (requires careful handling in a controlled environment)

Upstream product

• 4919-33-9 4-ethoxyphenylacetic acid 
• 29056-03-9 4-ethoxyphenylacetic acid methyl ester 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 

Downstream Products

• 855618-28-9 2-(4-ethoxy-phenyl)-1-[2]thienyl-ethanone 
• 101594-94-9 4'-ethoxy-4-methoxy-deoxybenzoin 
• 2132-57-2 4,4'-diethoxy-deoxybenzoin 
• 174533-59-6 4-Amino-3-[2-(4-ethoxy-phenyl)-acetylamino]-benzoic acid methyl ester 
• 474020-79-6 C₂₁H₂₅N₃O₅ 
• 359881-94-0 2-(4-ethoxyphenyl)-N-(4-methylbenzyl)-N-(1-methylpiperidin-4-yl)acetamide hydrochloride 
• 69788-78-9 6-ethoxy-3,4-dihydro-2(1H)-naphthalenone 
• 857971-93-8 2-(4-ethoxy-phenyl)-1-phenyl-1-[2]thienyl-ethanol 

Relevant articles and documents

C1 substituted 3, 4 - ISO-quinoline alkaloids of the preparation and its medicinal use

The invention belongs to the field of medical technology. The invention relates to a structure of the formula (I) indicated by the C1 substituted 3, 4 - ISO alkaloid or its pharmaceutically acceptable salt preparation method and medical use thereof. The invention to BOC - L - phenylalanine as raw materials, with 3, 4 - dimethoxyphenethylamine to N - acylated condensation and then remove the BOC group gets the (S)- 2 - amino - N - (3, 4 - dimethyl practiced with ethyl) - 3 - benzyl amide intermediate 1, intermediate 1 or phenethylamine derivatives with the prepared containing different substituent phenyllacetyl carries out amidation reaction, finally loop Bischler - Napieralski reaction. After activeness screening tests, the compounds of this invention possess pancrelipase inhibition, in the development into a lipase inhibitor and for preventing or treating hyperlipidemia, diabetes, obesity or metabolic syndrome and other diseases has a good application prospect.

COMPOUNDS, SALTS THEREOF AND METHODS FOR TREATMENT OF DISEASES

The present disclosure relates to compounds according to Formula (I), useful for treating diseases.

Discovery of a Potent, Selective T-type Calcium Channel Blocker as a Drug Candidate for the Treatment of Generalized Epilepsies

We report here the discovery and pharmacological characterization of N-(1-benzyl-1H-pyrazol-3-yl)-2-phenylacetamide derivatives as potent, selective, brain-penetrating T-type calcium channel blockers. Optimization focused mainly on solubility, brain penetration, and the search for an aminopyrazole metabolite that would be negative in an Ames test. This resulted in the preparation and complete characterization of compound 66b (ACT-709478), which has been selected as a clinical candidate.