103680-87-1

Basic information

• Product Name: Dihydrobonducellin
• Synonyms: Dihydrobonducellin;2,3-Dihydro-7-hydroxy-3-[(4-methoxyphenyl)methyl]-4H-1-benzopyran-4-one
• CAS NO: 103680-87-1
• Molecular Formula: C₁₇H₁₆O₄
• Molecular Weight: 284.30654
• Mol File: 103680-87-1.mol
• Article Data: 3

Chemical Properties

• Melting Point: 132-134 °C
• Boiling Point: 495.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.266±0.06 g/cm3(Predicted)
• PKA: 7.73±0.40(Predicted)
• CAS DataBase Reference: Dihydrobonducellin(CAS DataBase Reference)
• NIST Chemistry Reference: Dihydrobonducellin(103680-87-1)
• EPA Substance Registry System: Dihydrobonducellin(103680-87-1)

Safety Data

• Hazardous Substances Data: 103680-87-1(Hazardous Substances Data)

Usage

General Description

Dihydrobonducellin is a sesquiterpene lactone that is found in the roots of the medicinal plant Inula britannica. It exhibits potent anti-inflammatory, antibacterial, and cytotoxic activities. Dihydrobonducellin has been shown to inhibit the production of inflammatory mediators such as nitric oxide and prostaglandin E2, making it a potential therapeutic agent for the treatment of inflammatory diseases. Additionally, it has demonstrated significant antibacterial activity against various strains of bacteria, indicating its potential for use as an antimicrobial agent. Furthermore, dihydrobonducellin has displayed cytotoxic effects against cancer cell lines, showing promise as a potential anticancer agent. Its diverse biological activities make dihydrobonducellin an interesting target for further research and potential drug development.

Upstream product

• 83162-84-9 Bonducellin 
• 76240-27-2 7-hydroxy-2,3-dihydro-4H-chromen-4-one 
• 151884-07-0 2',4'-dihydroxy-3-chloropropiophenone 
• 108-46-3 recorcinol 
• 81674-92-2 (E)-1-(4-(benzyloxy)-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 
• 103680-83-7 4'-ethoxymethoxy-2'-hydroxy-α-hydroxymethyl-4-methoxydihydrochalcone 
• 104311-10-6 4'-ethoxymethoxy-2'-hydroxy-4-methoxy-dihydrochalcone 
• 93435-21-3 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)propane-1-one 
• 103680-85-9 3-(4-methoxy) benzyl, 7-ethoxymethoxy-4-chromanone 

Relevant articles and documents

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine-Homoisoflavonoid hybrids

A series of Tacrine-Homoisoflavonoid hybrids were designed, synthesised and evaluated as inhibitors of cholinesterases (ChEs) and human monoamine oxidases (MAOs). Most of the compounds were found to be potent against both ChEs and MAO-B. Among these hybrids, compound 8b, with a 6 carbon linker between tacrine and (E)-7-hydroxy-3-(4-methoxybenzylidene)chroman-4-one, proved to be the most potent against AChE and MAO-B with IC50 values of 67.9 nM and 0.401 μM, respectively. This compound was observed to cross the blood-brain barrier (BBB) in a parallel artificial membrane permeation assay for the BBB (PAMPA-BBB). The results indicated that compound 8b is an excellent multifunctional promising compound for development of novel drugs for Alzheimer's disease (AD).

A New Synthesis of Homoisoflavanones (3-Benzyl-4-chromanones)

7-Hydroxy-4'-methoxyhomoisoflavanone (5) has been synthesised from 2',4'-dihydroxy-4-methoxydihydrochalcone (1) by a new method involving ethoxymethylation of 4'-hydroxyl group to give 2, followed by hydroxymethylation of the bridge methylene in 2, heterocyclization of 3 and deprotection of 4.