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103686-53-9

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103686-53-9 Usage

General Description

1-Propanone, 2,2-dimethyl-1-(5-pyrimidinyl)- (9CI) is an organic compound with the chemical formula C11H14N2O. It is a derivative of 1-propanone with a 2,2-dimethyl-1-(5-pyrimidinyl) group attached to the carbon chain. 1-Propanone, 2,2-dimethyl-1-(5-pyrimidinyl)- (9CI) is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a building block in the production of various chemicals, including pesticides and herbicides. Additionally, it has potential applications in the field of medicinal chemistry for the development of new drugs. 1-Propanone, 2,2-dimethyl-1-(5-pyrimidinyl)- (9CI) is soluble in organic solvents and has low water solubility, making it suitable for use in organic synthesis and chemical reactions. Overall, this compound has diverse potential uses in the chemical and pharmaceutical industries due to its unique chemical structure and properties.

Check Digit Verification of cas no

The CAS Registry Mumber 103686-53-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,3,6,8 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 103686-53:
(8*1)+(7*0)+(6*3)+(5*6)+(4*8)+(3*6)+(2*5)+(1*3)=119
119 % 10 = 9
So 103686-53-9 is a valid CAS Registry Number.

103686-53-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2,2-dimethyl-1-pyrimidin-5-ylpropan-1-one

1.2 Other means of identification

Product number -
Other names tert.-butyl 5-pyrimidinyl ketone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:103686-53-9 SDS

103686-53-9Downstream Products

103686-53-9Relevant articles and documents

Development of a Practical Synthesis of a Pyrimidine Derivative with Fungicidal Activity

Ryan, Sarah J.,Yang, Qiang

, p. 2157 - 2165 (2019)

A scalable synthesis of a pyrimidine fungicide lead was developed. The pyrimidine head, 1-(5-bromopyridin-2-yl)-2,2-dimethyl-1-(pyrimidin-5-yl)propan-1-ol, was prepared by metal-halogen exchange of 2-iodo-5-bromopyridine with i-PrMgCl followed by treatment with pivaloyl chloride (PivCl) in the presence of CuCN·2LiCl and subsequent addition of 5-lithiopyrimidine. The boronic acid tail, (4-(1-cyanocyclobutyl)-2-fluorophenyl)boronic acid, was prepared via treatment of 1-(4-bromo-3-fluorophenyl)cyclobutane-1-carbonitrile with i-PrMgCl and trimethylborate. The o-fluoro Grignard reagent formed during this reaction sequence was analyzed by two-drop calorimetry and accelerating rate calorimetry, which revealed minimal safety concerns for scale-up. Finally, the boronic acid tail was coupled with the pyrimidine head in the presence of catalytic palladium acetate [Pd(OAc)2]/triphenylphosphine (PPh3) to deliver the final product in >95% yield after crystallization.

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