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6-Dimethylaminopyridine-3-boronic acid pinacol ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1036991-24-8 Structure
  • Basic information

    1. Product Name: 6-Dimethylaminopyridine-3-boronic acid pinacol ester
    2. Synonyms: 6-Dimethylaminopyridine-3-boronic acid pinacol ester;2-(Dimethylamino)pyridine-5-boronic acid pinacol ester;N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine(SALTDATA: FREE);N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinamine;N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)
    3. CAS NO:1036991-24-8
    4. Molecular Formula: C13H21BN2O2
    5. Molecular Weight: 266.14432
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1036991-24-8.mol
  • Chemical Properties

    1. Melting Point: 89-90 °C
    2. Boiling Point: 358.5±27.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.04±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
    8. Solubility: N/A
    9. PKA: 6.98±0.10(Predicted)
    10. CAS DataBase Reference: 6-Dimethylaminopyridine-3-boronic acid pinacol ester(CAS DataBase Reference)
    11. NIST Chemistry Reference: 6-Dimethylaminopyridine-3-boronic acid pinacol ester(1036991-24-8)
    12. EPA Substance Registry System: 6-Dimethylaminopyridine-3-boronic acid pinacol ester(1036991-24-8)
  • Safety Data

    1. Hazard Codes: Xi
    2. Statements: 43
    3. Safety Statements: 36/37
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1036991-24-8(Hazardous Substances Data)

1036991-24-8 Usage

Uses

6-(Dimethylamino)pyridine-3-boronic acid pinacol ester

Check Digit Verification of cas no

The CAS Registry Mumber 1036991-24-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,3,6,9,9 and 1 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1036991-24:
(9*1)+(8*0)+(7*3)+(6*6)+(5*9)+(4*9)+(3*1)+(2*2)+(1*4)=158
158 % 10 = 8
So 1036991-24-8 is a valid CAS Registry Number.
InChI:InChI=1S/C13H21BN2O2/c1-12(2)13(3,4)18-14(17-12)10-7-8-11(15-9-10)16(5)6/h7-9H,1-6H3

1036991-24-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

1.2 Other means of identification

Product number -
Other names N,N-dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1036991-24-8 SDS

1036991-24-8Relevant articles and documents

Cobalt-catalyzed C-H borylation

Obligacion, Jennifer V.,Semproni, Scott P.,Chirik, Paul J.

, p. 4133 - 4136 (2014)

A family of pincer-ligated cobalt complexes has been synthesized and are active for the catalytic C-H borylation of heterocycles and arenes. The cobalt catalysts operate with high activity and under mild conditions and do not require excess borane reagents. Up to 5000 turnovers for methyl furan-2-carboxylate have been observed at ambient temperature with 0.02 mol % catalyst loadings. A catalytic cycle that relies on a cobalt(I)-(III) redox couple is proposed.

Cyclopalladated ferrocenylimine as efficient catalyst for the syntheses of arylboronate esters

Wang, Lianhui,Li, Jingya,Cui, Xiuling,Wu, Yusheng,Zhu, Zhiwu,Wu, Yangjie

, p. 2002 - 2010 (2010)

The cyclopalladated ferrocenylimine I and its phosphine adducts IIa-f were prepared and evaluated in the borylation of aryl halides. The tricyclohexylphosphine adduct IIb exhibited highly catalytic activity for the coupling of aryl and heteroaryl bromides containing various functional groups with low catalyst loading (2 mol%). Aryl and heteroaryl chlorides were smoothly converted into the corresponding boronates in the presence of the monophosphinobiaryl ligand (XPhos) adduct IIf. It was proposed that palladacycle was only a reservoir of the catalytically active species from the investigation on the reaction mechanism.

DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY

-

Page/Page column 380; 381, (2019/11/12)

Provided herein are compounds of the Formula (I), (II), and (III), as well as pharmaceutically acceptable salts thereof, wherein the substituents are those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of oncologic diseases.

SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE

-

Page/Page column 262, (2017/08/01)

The present invention provides compounds of Formula (I) or a subgeneric structure or species thereof, or a pharmaceutically acceptable salt, ester, solvate, and/or prodrug thereof, and methods and compositions for treating or ameliorating abnormal cell proliferative disorders, such as cancer, wherein A, R2, R3, R10, E1, E2, E3, Y, and Z are as defined herein.

SUBSTITUTED BENZAZINONES AS ANTIBACTERIAL COMPOUNDS

-

Page/Page column 248, (2017/07/14)

The present invention relates to LpxC antibacterial compounds of Formula (1A), corresponding pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions:, compound preparation, treatment methods and uses for bacterial infections, especially those caused by gram-negative bacteria.

BASE METAL CATALYZED BORYLATION OF ARENES AND AROMMATIC HETEROCYCLES

-

Page/Page column 34, (2015/06/25)

In one aspect, cobalt complexes are described herein. In some embodiments, such cobalt complexes employ bis(phosphine) or bis(imine) ligand and are operable as catalysts for borylation of arenes and aromatic heterocycles.

PHOSPHOINOSITIDE 3-KINASE INHIBITORS WITH ZINC BINDING MOIETY

-

Paragraph 0296; 0419, (2016/10/07)

PROBLEM TO BE SOLVED: To provide phosphoinositide 3-kinase inhibitors with a zinc binding moiety. SOLUTION: There is provided a compound represented by formula (I) in the figure. (X is S, O or the like; Y is CH, N or the like; G1 is optionally substituted N or the like; R1 and R2 are each independently H or the like; C is a substituted heterocycle or the like; B is a linear alkyl or the like; Ra and Rb together with the nitrogen atom coupled to them are morpholino or the like; G2 is an indazole ring or the like; q, r and s are independently from 0 to 1, provided that at least one of them is 1; t is from 0 to 1; n is from 0 to 4; and p is from 0 to 2.) COPYRIGHT: (C)2016,JPOandINPIT

SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS

-

Paragraph 0161; 0162; 0163, (2014/05/08)

Provided are pyridopyrazine compounds of formula (1), pharmaceutical compositions thereof and methods of use therefore, wherein R1, R2, R3, R4 and m are as defined in the specification.

TREATMENT OF CANCERS HAVING K-RAS MUTATIONS

-

Paragraph 0487, (2013/05/08)

The present invention provides a method of treating a cancer associated with a K-ras mutation in a subject in need thereof. The method comprises the steps of: (1) identifying a subject with a cancer associated with a K-ras mutation; and (2) administering to the subject (i) an inhibitor of PI3 kinase and (ii) an HDAC inhibitor, wherein the PI3 kinase inhibitor and the HDAC inhibitor are administered in amounts which together are therapeutically effective.

Synthesis of biaryls through a one-pot tandem borylation/Suzuki-Miyaura cross-coupling reaction catalyzed by a palladacycle

Wang, Lianhui,Cui, Xiuling,Li, Jingya,Wu, Yusheng,Zhu, Zhiwu,Wu, Yangjie

experimental part, p. 595 - 603 (2012/03/09)

The tricyclohexylphosphane adduct of cyclopalladated ferrocenylimine I exhibited high catalytic activity in the one-pot borylation/Suzuki-Miyaura coupling (BSC) reaction with low catalyst loading (2 mol-%). Various biaryls were obtained in good to excellent yields for 37 examples. This process was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups and did not require an excess amount of phosphane ligand and the addition of the palladium catalyst in the second step. Cyclopalladated ferrocenylimine I exhibited high catalytic activity in the borylation/Suzuki- Miyaura coupling (BSC) reaction with low catalyst loading. Various unsymmetrical biaryls were obtained ingood to excellent yields in one pot. This protocol was applied to aryl and heteroaryl halides (Br and Cl) containing a variety of functional groups without adding catalyst in the second step. Copyright

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