1037070-06-6Relevant articles and documents
Synthesis and anticancer activity of chalcone-pyrrolobenzodiazepine conjugates linked via 1,2,3-triazole ring side-armed with alkane spacers
Kamal, Ahmed,Prabhakar,Janaki Ramaiah,Venkat Reddy,Ratna Reddy, Ch.,Mallareddy,Shankaraiah, Nagula,Lakshmi Narayan Reddy,Pushpavalli,Pal-Bhadra, Manika
, p. 3820 - 3831 (2011)
Aiming to develop multitarget drugs for the anticancer treatment, a new class of chalcone-pyrrolo[2,1-c] [1,4]benzodiazepine (PBD) conjugates linked through a 1,2,3-triazole moiety containing alkane spacers has been designed and synthesized. Combining the
Synthesis and biological evaluation of estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (PBD) conjugates as potential anticancer agents
Kamal, Ahmed,Kashi Reddy,Janaki Ramaiah,Rajender,Surendranadha Reddy,Srikanth,Dastagiri,Vijaya Bharathi,Pushpavalli,Sarma, Pranjal,Pal-Bhadra, Manika
experimental part, p. 2565 - 2581 (2011/06/09)
A series of new estradiol linked pyrrolo[2,1-c][1,4]benzodiazepine (E 2-PBD) conjugates (3a-f, 4a-f and 5a-f) with different linker architectures including a triazole moiety have been designed and synthesized. All the 18 compounds have been eva
Synthesis of C8-C8/C2-C8-linked triazolo pyrrolobenzodiazepine dimers by employing 'click' chemistry and their DNA-binding affinity
Kamal, Ahmed,Prabhakar,Shankaraiah,Reddy, Ch. Ratna,Reddy, P. Venkat
, p. 3620 - 3624 (2008/09/21)
A series of 1,2,3-triazole-containing pyrrolo[2,1-c][1,4]benzodiazepine dimers have been prepared efficiently by employing a 'click' chemistry protocol. This method involves 1,3-dipolar cycloaddition of terminal alkynes with organic azides using a Cu(I)-c