1037183-97-3Relevant academic research and scientific papers
INHIBITION OF BACTERIAL BIOFILMS WITH IMIDAZOLE-PHENYL DERIVATIVES
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Page/Page column 47-48; 61, (2009/10/30)
Disclosure is provided for imidazole-phenyl derivative compounds that prevent, remove and/or inhibit the formation of biofilms, compositions comprising these compounds, devices comprising these compounds, and methods of using the same.
Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the sonogashira reaction
Richards, Justin J.,Melander, Christian
, p. 5191 - 5193 (2008/12/20)
(Chemical Equation Presented) The divergent synthesis of a 21-member library composed of 2-aminoimidazole compounds for evaluation as novel antibiofilm molecules is presented. The Sonogashira reaction was employed with three regioisomeric aryl iodides and 11 different alkynes to generate variously substituted diverse ring systems. Good to excellent yields (80-97%) for the reaction were obtained, and the products provide adequate handles for further manipulation into more advanced analogues.
