1037211-53-2Relevant academic research and scientific papers
Discovery of a potent and orally active hedgehog pathway antagonist (IPI-926)
, p. 4400 - 4418 (2009)
Recent evidence suggests that blocking aberrant hedgehog pathway signaling may be a promising therapeutic strategy for the treatment of several types of cancer. Cyclopamine, a plant Veratrum alkaloid, is a natural product antagonist of the hedgehog pathwa
CYCLOPAMINE ANALOGS
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Page/Page column 57-58; 63-64, (2008/12/07)
The invention provides novel derivatives of cyclopamine having the following formula.
