1037295-13-8Relevant articles and documents
Benzylic C-H activation and C-O bond formation via aryl to benzylic 1,4-palladium migrations
Kesharwani, Tanay,Larock, Richard C.
, p. 6090 - 6102 (2008/09/21)
A procedure for benzylic C-H activation has been developed using a palladium 1,4-aryl to benzylic migration as a key step. Carboxylates and phenoxides readily trap the resulting benzylic palladium intermediates obtained from palladium 'through space' migration. Aryl bromides and iodides have been successfully employed in this reaction, furnishing moderate to good yields. The mechanism of this reaction has been studied by deuterium-labeling experiments, which suggest that the migration of palladium from an aryl to a benzylic position occurs reversibly. The reaction conditions developed for the migration process also oxidize the neighboring benzylic alcohols to the corresponding aldehydes and ketones.
