1037305-43-3Relevant articles and documents
Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras
Langner, Heera K.,Jastrzebska, Katarzyna,Caruthers, Marvin H.
, p. 16240 - 16253 (2020)
This Article outlines the optimized chemical synthesis and preliminary biochemical characterization of a new oligonucleotide analogue called thiophosphoramidate morpholinos (TMOs). Their rational design hinges upon integrating two well-studied pharmacopho
Synthesis and properties of morpholino chimeric oligonucleotides
Zhang, Nan,Tan, Chunyan,Cai, Puqin,Jiang, Yuyang,Zhang, Peizhuo,Zhao, Yufen
, p. 3570 - 3573 (2008)
Chimeric oligonucleotides with the novel morpholino modification and the phosphoramidate linkers have been synthesized and characterized. These oligonucleotides showed moderate thermal stability with complementary RNA and DNA, and enhanced resistance towa