143485-05-6

Basic information

• Product Name: 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine
• Synonyms: 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine
• CAS NO: 143485-05-6
• Molecular Weight: 543.62
• Mol File: 143485-05-6.mol

Chemical Properties

• CAS DataBase Reference: 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine(CAS DataBase Reference)
• NIST Chemistry Reference: 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine(143485-05-6)
• EPA Substance Registry System: 7'-O-(4,4'-dimethoxytrityl)-5-methylmorpholino uridine(143485-05-6)

Safety Data

• Hazardous Substances Data: 143485-05-6(Hazardous Substances Data)

Upstream product

• 138239-62-0 1-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione 
• 4336-39-4 (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate 
• 861355-55-7 2,4-dimethoxytrityl chloride 
• 56787-28-1 2',3',5'-tri-O-acetylcytidine 

Downstream Products

• 1037305-43-3 6'-O-(4,4'-dimethoxytrityl)-3'-O-cyanoethyl-1'-(N¹-thymidine) morpholino (N,N-diisopropylamino) phosphorodiamidite 

Relevant articles and documents

Synthesis and Characterization of Thiophosphoramidate Morpholino Oligonucleotides and Chimeras

This Article outlines the optimized chemical synthesis and preliminary biochemical characterization of a new oligonucleotide analogue called thiophosphoramidate morpholinos (TMOs). Their rational design hinges upon integrating two well-studied pharmacopho

SYNTHESIS OF BACKBONE MODIFIED MORPHOLINO OLIGONUCLEOTIDES AND CHIMERAS USING PHOSPHORAMIDITE CHEMISTRY

Amine substituted morpholino oligonucleotides, other than the classical N,N-dimethylamino PMO analogue, and methods of efficiently synthesizing these oligonucleotides with high yield are provided. Morpholino oligonucleotides having thiophosphoramidate, ph

RETRACTED ARTICLE: Synthesis of Phosphorodiamidate Morpholino Oligonucleotides and Their Chimeras Using Phosphoramidite Chemistry

Phosphorodiamidate morpholinos (PMOs) and PMO-DNA chimeras have been prepared on DNA synthesizers using phosphoramidite chemistry. This was possible by first generating boranephosphoroamidate morpholino internucleotide linkages followed by oxidative subst

Synthesis of triazole-linked morpholino oligonucleotides via CuI catalysed cycloaddition

Triazole-linked morpholino (TLMO) oligonucleic acids were synthesised using the CuI catalysed (3 + 2) azide-alkyne cycloaddition (CuAAC) reaction. The modified DNA analogues were incorporated into 13-mer sequences via solid phase syn

Synthesis and properties of morpholino chimeric oligonucleotides

Chimeric oligonucleotides with the novel morpholino modification and the phosphoramidate linkers have been synthesized and characterized. These oligonucleotides showed moderate thermal stability with complementary RNA and DNA, and enhanced resistance towa