1037308-52-3Relevant academic research and scientific papers
Amide as an efficient ligand in the palladium-catalyzed Suzuki coupling reaction in water/ethanol under aerobic conditions
Liu, Hai Yang,Wang, Kun,Fu, Hai Yan,Yuan, Mao Lin,Chen, Hua,Li, Rui Xiang
, p. 738 - 740 (2011)
Amide, which is derived from proline and is inexpensive and air-stable, has been synthesized and characterized by 1H NMR, 13C NMR, and MS. It was found to be an efficient ligand in the palladium-catalyzed Suzuki cross-coupling reaction. In the Pd/amide catalytic system, aryl bromides can be coupled with phenylboronic acid in ethanol/water (1:2; v/v) in excellent yields even with a low Pd loading of 0.01 mol%. Moreover, the scope of the reaction is broad, and a wide variety of functional groups are tolerant.
