103733-14-8

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 19337-34-9 thiobutyric acid S-pyridin-2-yl ester 
• 103733-13-7 (3R,4S)-3-Ethyl-1-(4-methoxy-phenyl)-4-((E)-styryl)-azetidin-2-one 
• 88315-63-3 (E)-4-methoxy-N-((E)-3-phenylallylidene)aniline 
• 1885-38-7 cinnamic nitrile 

Downstream Products

• 103733-19-3 (3R,4S)-1-(tert-Butyl-dimethyl-silanyl)-3-ethyl-4-((E)-styryl)-azetidin-2-one 

Relevant academic research and scientific papers

Soluble-polymer-supported synthesis of β-lactams on a modified poly(ethylene glycol)

A modified poly(ethylene glycol) (PEG) has been developed for the soluble-polymer-supported synthesis of β-lactams. The monomethylether of PEG (MeOPEG) with an average Mw of 5000 was used as the support, a 4-(3-propyl)phenyl residue as the spacer, and a 4-oxyphenylamino group as the moiety with the reactive functionality. From this modified PEG representative aromatic, heteroaromatic, unsaturated, and aliphatic imines were obtained in high yields by different procedures. The polymer-supported imines were then employed to prepare several β-lactams by enolate/imine condensation and ketene/ imine cycloaddition. Examples of the control of the absolute stereochemistry during the azetidinone ring formation are also reported. The reactions carried out on the polymer-bound imines showed a remarkable similarity to those performed on nonimmobilized imines, both in terms of yields and stereoselectivities. Removal of the β-lactams from the polymer has also been accomplished to directly deliver the N-unsubstituted azetidinones.

Beta-lactams as anticholesterolemic agents

Compounds of formula (I), which are useful as antihypercholesterolemic agents, are disclosed. STR1

A SYNTHETIC APPROACH TO AZETIDINONES FROM NITRILES AND LITHIUMTRIETHOXYALUMINIUM HYDRIDE.

A convenient one-pot process for direct conversion of nitriles to 3,4-disubstituted azetidinones has been developed.