103754-08-1Relevant articles and documents
Selective hydrosilylation of N-allylimines using a (3-iminophosphine)palladium precatalyst
Tafazolian, Hosein,Schmidt, Joseph A.R.
, p. 685 - 689 (2016/02/18)
Hydrosilylation utilizing a (3-iminophosphine)palladium catalyst leads to the selective reduction of the imine unit of allylimines. Successful reduction of twenty-five different substituted aromatic and alkyl allylimines demonstrated the scope and selecti
Experimental and computational study of 6- Exo and 7- Endo cyclization of aryl radicals followed by Tandem SRN1 Substitution
Peisino, Lucas E.,Pierini, Adriana B.
, p. 4719 - 4729 (2013/07/11)
The reaction of N-allyl-N-(2-halobenzyl)-acetamides and derivatives was investigated in liquid ammonia under irradiation with the nucleophiles Me 3Sn-, Ph2P- and O 2NCH2-. Following this procedure, novel substituted 2-acetyl-1,2,3,4-tetrahydroisoquinolines and substituted 2-acetyl-2,3,4,5-tetrahydro-1H-benzo[c]azepines were obtained in good yields. These reactions are proposed to occur through the intermediacy of aryl radicals, which by intramolecular 6-exo or 7-endo attack to a double bond cyclize to give aliphatic radicals, which react along the propagation steps of the S RN1 chain cycle to afford the cyclic substituted compounds as main products. The reactions were modeled with DFT methods, which provide a rational understanding that relates the product distribution to the structure of the aliphatic radicals proposed as intermediates and the kinetic of their formation.
